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amg 487

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  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
AMG 487
T10297L473719-41-4
AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
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(±)-AMG 487
T22477
AMG 487 is an effective and selective antagonist of chemokine receptor 3. AMG 487 inhibited CXCR3-mediated cell migration induced by three CXCR3 chemokines, IP-10, ITAC and MIG (IC50: 8, 15 and 36 nM, respectively).
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AMG 487 (S-enantiomer)
T10297473720-30-8
AMG 487 S-enantiomer, the S enantiomer of AMG 487, is a CXCR3 antagonist.
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6-8 weeks
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