aldehyde oxidase

Isovanillin (5-Formylguaiacol) is a reversible inhibitor of aldehyde oxidase. It is largely used as pharmaceutical intermediates and also applied in food and beverage industry, synthetic fragrances, chemical.

aldehyde oxidase (AO) substrate

Quinacrine is a compound that is commonly used as an anti-protozoal agent. It inhibits voltage-dependent sodium channels (IC50: 3.3 μM) and suppresses aldehyde oxidase (IC50: 3.3 μM). Quinacrine prevents misfolding of prion protein (EC50: 0.3 μM). As an e

6-Formylpterin (Pterin-6-aldehyde) is an inhibitor of Xanthine Oxidase (Ki ~0.6 nM) with potent neuroprotective effects against transient IRI in gerbils.6-Formylpterin induces intracellular ROS generation in HL-60 cells as well as apoptosis ( 6-Formylpterin inhibits the expression of iNOS, produces hydrogen peroxide intracellularly and restores the impaired bactericidal activity of human neutrophils.

DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.[1] It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET). DOPAL is toxic to neurons.[2],[3] It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson's disease.[2] Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as well as neurodegeneration and motor dysfunction characteristic of Parkinson's disease.[4]

6-ethenylquinoline is a structurally unique aromatic heterocyclic compound that is an important intermediate in the production of other aromatic compounds. It has also been used as a starting material for the synthesis of a variety of drugs, including antifungal, antiparasitic and antiviral agents. It has been shown to be an inhibitor of a variety of enzymes involved in drug metabolism, including cytochrome P450, aldehyde oxidase and xanthine oxidase.

JAK-IN-19 is a potent JAK inhibitor with pIC50 values of 7.2 for PBMC (IFNγ) and 7.7 for HLF (Eotaxin). The compound also exhibits pIC50 values of 7.0 for VEGFR2 and 5.8 for Aurora B.

3-Furaldehyde is an inhibitor of polyphenol oxidase 2 and aldehyde oxidase 1 and can be used in biochemical experiments and drug synthesis.

Choline oxidase is an enzyme that facilitates the conversion of choline to glycine betaine through an intermediate, betaine aldehyde, during the synthesis of glycine betaine. Glycine betaine serves as an osmolyte. Furthermore, choline oxidase shows promise for use in the enzymatic production of betaine [1].

6-Nitroquinazoline, an antimalarial agent, is also a substrate for human liver aldehyde oxidase [1].

SP3N acts as a specific degrader of the prolyl isomerase FKBP12, converting through amine oxidase metabolism into the active aldehyde precursor (SP3CHO). This compound subsequently recruits the SCFFBXO22 E3 ligase to mediate the degradation of FKBP12. SP3N is employed in research for cancer therapy.

UNC8732 is a Targeted Protein Degradation (TPD) agent. It acts by catalyzing the production of aldehyde metabolites through amine oxidase, which subsequently binds to the C326 of the ubiquitin E3 ligase FBXO22, recruiting the SCFFBXO22 Cullin complex. This recruitment leads to the further degradation of the histone methyltransferase and the oncogene NSD2.

(+)-Abscisic Aldehyde (ABAld) is an intermediate product in the biosynthetic pathway of the plant hormone Abscisic Acid (ABA). It is produced from flavanone through dehydrogenation by flavanone dehydrogenase, followed by selective oxidation by abscisic aldehyde oxidase. This compound possesses oxidation activity for PsAOγ and is associated with ABA accumulation in the older leaves of pea plants under prolonged exposure to salinity, ammonium, or nitrogen deficiency. (+)-Abscisic Aldehyde is useful for research in plant growth and development.