adenylyl cyclase 1(ac1)

NB001 (HTS 09836) is an adenyl cyclase 1 inhibitor that affects both neural and non-neural pain.

ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).

AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).

Wnt pathway inhibitor 3 is a potent AC1 inhibitor (IC50: 45 nM) with antiproliferative activity, suitable for studies to ameliorate osteoarthritis in a mouse model of experimental osteoarthritis.

2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate (2'-ANT-GTP) and 3'-ANT-GTP are fluorescent derivatives of GTP that exhibit spontaneous isomerization. 2'(3')-ANT-GTP features an emission peak at 428 nm when excited at 330 nm in aqueous conditions. It functions as an inhibitor of several adenylyl cyclases, notably mammalian adenylyl cyclase 1 (AC1; Ki = 10 nM with manganese), inhibits B. anthracis adenylyl cyclase toxin edema factor (Kis = 4.1 and 13 µM with manganese and magnesium, respectively), and B. pertussis adenylyl cyclase toxin CyaA (Ki = 29 µM with manganese).