adam17/tace

IK-862 is a selective inhibitor of TACE (ADAM17).

TAPI1 (TAPI) , an ADAM17 TACE inhibitor, inhibits shedding of cytokine receptors.

BMS-561392 Formic acid is a selective inhibitor of TACE and reduces TNFalpha levels.

(S,S)-TAPI-1, an isomer of TAPI-1, is a metalloproteinase (MMP) inhibitor and a TACE (ADAM17) inhibitor known for its potent inhibition of various cell surface protein shedding.

GW280264X (Carbamic acid) is an inhibitor of ADAM17 .

TMI-1 (WAY-171318), a novel orally active inhibitor of ADAM17 (TACE) and MMP, induces tumor apoptosis in a breast cancer.

TAPI-1 is an ADAM17 TACE inhibitor, which blocks shedding of cytokine receptors.

TAPI1 acetate is a salt form of TAPI1. TAPI1 (TNF-α processing inhibitor-1) is a TACE (ADAM17) inhibitor that inhibits shedding of TNF-α, TNFRI (p60), and TNFRII (p80), IL-6 other cytokine receptors; TAPI-1 is also a metalloproteinase MMP inhibitor that promotes cisplatin-induced ESCC cell apoptosis by inhibiting the NF-κB signaling pathway to promote cisplatin-induced apoptosis in ESCC cells.

KP-457 is a specific inhibitor of a disintegrin-metalloproteinase 17 (ADAM17) and a TNFα converting enzyme TACE inhibitor that blocks the production of soluble TNF (sTNF).

BMS-561392 formate, the formate derivative of BMS-561392, functions as a TNF alpha-converting enzyme (TACE) inhibitor and an ADAM17 blocker. It is utilized in the research of inflammatory bowel disease [1] [2].