T1226

Bacitracin (Ziba-RX), a mixture of related cyclic polypeptides, disrupts bacteria by interfering with cell wall and peptidoglycan synthesis.

NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100. This compound facilitates nerve functional recovery following neurodegeneration in vivo.

Ilginatinib maleate (NS-018 maleate) is a highly active, orally bioavailable inhibitor of JAK2.

NSC117079 is a novel PHLPP1/2 (Pleckstrin homology domain and leucine rich repeat protein phosphatase) inhibitor that activates neuronal AKT and ameliorates staurosporine-induced cell death in neurons.

NSC232003 is a highly potent and cell-permeable inhibitor of [UHRF1].

NPS ALX Compound 4a is a potent and selective antagonist of the 5-HT6 receptor with an IC50 of 7.2 nM.

NPS ALX Compound 4a dihydrochloride is a potent and selective antagonist of the 5-HT6 receptor with an IC50 of 7.2 nM.

NSC305787 is an ezrin inhibitor with antitumor activity, inhibits PKCΙ-induced ezrin phosphorylation, reduces β2AR expression in the cell membrane, and induces intracellular vesicular or punctate expression of ezrin and β2AR, and can be used to study pancreatic cancer.

NSC305787 hydrochloride ((Rac)-NSC305787 hydrochloride is a cell membrane permeable and selective and potent small molecule dual inhibitor of Cdc25 dual specificity phosphatase and EZR that displays antitumor activity in pancreatic cancer cells and inhibits Cdc25B2, Cdc25A, Cdc25B2 and Cdc25C.NSC 663284 inhibits NSD2 (IC50 of 170 nM) enzyme activity.

Fludazonium chloride (NSC-351149) is an antifungal agent.

NSC624206 (N-(2-((p-Chlorobenzyl)dithio)ethyl)decylamine hydrochloride) is an asymmetric disulfide small molecule that acts as a selective inhibitor of the ubiquitin-activating enzyme E1 (UBA1). It effectively blocks the in vitro ubiquitination-mediated degradation of the cell cycle regulator p27 and induces the accumulation of p27 protein in the HepG2 liver cancer cell model.

Ilginatinib (NS-018) is a highly active, orally bioavailable JAK2 inhibitor.

Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active, orally bioavailable JAK2 inhibitor.

NSP-805 is a potent and selective inhibitor of guinea pig cardiac phosphodiesterase 3 (PDE3).

NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)

NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.