proteasome-in-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12561	Proteasome-IN-1		Proteasome
	Proteasome-IN-1 is an inhibitor of proteasome.		Proteasome
T81373	Proteasome β2c/i-IN-1		Proteasome
	Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].		Proteasome
T63321	20S Proteasome activator 1		Proteasome
	20S Proteasome activator 1 is a 20S proteasome activator with IC50 of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites and 1.8 μM for caspase sites. 20S Proteasome activator 1 prevents the accumulation o...		Proteasome
T77620	LMTK3-IN-1		c-Met/HGFR
	Lmtk3-in-1 is a potent ATP-competitive lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM) inhibitor that degrades LMTK3 through the ubiquitin proteasome pathway. LMTK3-IN-1 has shown anticancer activity in a variety of cancer c...		c-Met/HGFR
T12818	S119-8		Influenza Virus
	RN-18 antagonizes Vif function and inhibits HIV-1 replication only in the presence of A3G. RN-18 increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting gen...		Influenza Virus
T2S1837	Steviol	NSC 226902,Hydroxydehydrostevic acid	Others
	1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the prolif...		Others
T81371	Proteasome-IN-5		Proteasome
	Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].		Proteasome
T16795	Rpn11-IN-1	Capzimin intermediate	Others
	Rpn11-IN-1 is an effective and selective inhibitor of proteasome subunit Rpn11 (IC50: 390 nM).		Others
T76243	Proteasome-activating peptide 1 TFA
	Proteasome-activating peptide 1 TFA is a potent activator of the proteasome, enhancing chymotrypsin-like proteasomal catalytic activity and thereby increasing proteolytic rates both in vitro and in culture. Additionally,...
T62255	20S Proteasome-IN-4
	20S Proteasome-IN-4 (Compound 7) is an orally active inhibitor of the 20S proteasome, selectively targeting the parasite form and demonstrating brain penetration capabilities. It exhibits a potent IC50 value of 6.3 nM ag...
T81372	Proteasome-activating peptide 1
	Proteasome-activating peptide 1 enhances chymotrypsin-like proteasomal catalytic activity, boosting proteolytic rates both in vitro and within cultured cells. Additionally, it inhibits protein aggregation in a cellular m...
T68869	TP-110
	TP-110 is a new proteasome inhibitor, which shows potent growth inhibition in various tumor cell lines. Treatment with TP-110 for 24 h in vitro induced apoptosis in multiple myeloma cell line RPMI8226. TP-110 reduced the...
T78847	BC-05		Others
	BC-05, an orally active inhibitor targeting CD13 and the proteasome, displays potent inhibition with IC50 values of 0.13 μM against human CD13 and 1.39 μM for the 20S proteasome. It is utilized in the research of multipl...		Others
T40255	VCP/p97 inhibitor-1	VCP/p97 inhibitor-1
	VCP/p97 inhibitor-1, a highly effective compound, inhibits VCP/p97 (also known as Cdc48, CDC-48, or Ter94) with an IC 50 of 54.7 nM. This inhibitor induces a disruption in protein homeostasis and interferes with the degr...
T75870	PR-39 TFA
	PR-39 TFA, a natural peptide rich in proline and arginine with antibacterial properties, acts as a noncompetitive, reversible, and allosteric inhibitor of the proteasome. It specifically attaches to the α7 subunit of the...
T75869	PSI TFA
	PSI (TFA) is a potent proteasome inhibitor effective against the proliferation of primary effusion lymphoma (PEL) cells, utilized in the study of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and related lymph...
T69880	YW2065
	YW2065 has excellent anti-colorectal cancer effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-...
T76038	Ac-Nle-Pro-Nle-Asp-AMC
	Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for the 26S proteasome and is utilized in analyzing the proteasome's caspase-like activity [1] [2] [3].
T79474	GSPT1 degrader-1		Apoptosis
	GSPT1 Degrader-1 (Compound 9q) effectively facilitates the degradation of G1 to S phase transition 1 (GSPT1) through the ubiquitin-proteasome system and induces G0/G1 phase arrest and apoptosis in cells [1].		Apoptosis
T80129	Baceridin		Proteasome
	Baceridin, a cyclic hexapeptide and proteasome inhibitor, can be isolated from the culture medium of Epiphytic Bacillus. It has the ability to impede cell cycle progression and induce apoptosis in tumor cells via a p53-i...		Proteasome