docetaxel — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1034	Docetaxel	NSC 628503,RP-56976	Apoptosis , Microtubule Associated , Endogenous Metabolite
	Docetaxel (RP-56976) is a semi-synthetic analog of paclitaxel, a microtubule depolymerization inhibitor (IC50=0.2 μM). Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing,...		Apoptosis , Microtubule Associated , Endogenous Metabolite
T0186	Docetaxel trihydrate	RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate	Apoptosis , BCL , Microtubule Associated
	Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the therapy of many solid tumor i...		Apoptosis , BCL , Microtubule Associated
TQ0142	10-Oxo Docetaxel	Docetaxel Impurity 1	Others
	10-Oxo Docetaxel is a Docetaxel intermediate having remarkable antitumor properties.		Others
T19163	7-Epi-10-oxo-docetaxel	Docetaxel Impurity 2	Others
	7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) is an impurity of docetaxel detected by HPLC.		Others
TQ0247	7-Epi-docetaxel	7-Epidocetaxel,4-epi-Docetaxel,7-Epitaxotere	Others
	7-Epi-10-oxo-docetaxel (7-Epitaxotere) is a impurity of docetaxel.		Others
T38644	Docetaxal	PNU-101383,10-Acetyl docetaxel
	Docetaxal, also known as 10-Acetyl docetaxel, is an analog of Docetaxel exhibiting potent anticancer properties. It acts as a microtubule disassembly inhibitor, effectively inhibiting mitosis.
T74418	Sudocetaxel
	Sudocetaxel is a compound that serves as a microtubule depolymerization inhibitor, specifically designed for the pH-sensitive delivery of docetaxel.
T11122	DUPA(OtBu)-OH		Others
	DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer. PSMA has a high affinity ...		Others
T15713	Larotaxel	XRP9881	P-gp
	Larotaxel (XRP9881) is a taxane analogue that has anticancer activity, exerts its cytotoxic effects by promoting tubulin assembly and stabilizing microtubules, and ultimately induces cell death through apoptosis. Larotax...		P-gp
T2543	Cabazitaxel	XRP6258,RPR-116258A,TXD 258,taxoid XRP6258	Microtubule Associated , Autophagy
	Cabazitaxel (taxoid XRP6258) is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docetaxel.		Microtubule Associated , Autophagy
T60372	ALDH3A1-IN-1
	ALDH3A1-IN-1 (Compound 18) is a potent ALDH3A1 inhibitor with an IC 50 of 1.61 μM. ALDH3A1-IN-1 is more potent than DEAB against patient-derived primary prostate tumor epithelial cells, as single agents or in combination...
T6695	Tasquinimod	ABR-215050	HDAC
	Tasquinimod (ABR-215050) is a quinoline-3-carboxamide linomide analog with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease blood vessel density but the exact mechanism of ac...		HDAC
TP2051	CTCE-9908	CTCE 9908
	CXCR4 antagonist; induces mitotic catastrophe in ovarian cancer cells. Displays additive cytotoxic effects when given with taxol. Enhances the efficacy of docetaxel in a mouse model.
T15514	Hydroxy-PEG10-Boc		Others
	Hydroxy-PEG10-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG10-Boc can be conjugated to Paclitaxel or docetaxel [2].		Others
T28216	NTRC 0066-0	NTRC-0066-0,NTRC-00660,NTRC00660,NTRC0066-0
	NTRC-0066-0 is a a highly potent and selective inhibitor of TTK. NTRC 0066-0 inhibits the phosphorylation of a TTK substrate and induces chromosome missegregation. NTRC 0066-0 inhibits tumor growth in MDA-MB-231 xenograf...
T82327	GEM–IB
	Gemcitabine-ibandronate (GEM–IB), a conjugate of gemcitabine (GEM)-5'-phosphate with ibandronate (IB), exhibits efficacy both as a monotherapy and synergistically with Docetaxel (DTX), resulting in diminished tumor burde...