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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T63208 | Aβ-IN-1 | Gamma-secretase | |
Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ-IN-1 shows a sustained pharma... | |||
T63208L | Aβ-IN-1 TFA | Aβ-IN-1 TFA(2766509-32-2 Free base) | |
Aβ-IN-1 TFA inhibits and reverses different types of protein aggregation. | |||
T39781 | Aβ/tau aggregation-IN-1 | ||
Aβ/tau aggregation-IN-1 is a potent inhibitor of Aβ 1-42 β-sheet formation and tau aggregation. It exhibits K D values of 160 μM and 337 μM with Aβ 1-42 and tau, respectively. Additionally, Aβ/tau aggregation-IN-1 can pe... | |||
T79569 | AChE/Aβ-IN-1 | ||
AChE/Aβ-IN-1 (compound 32) is a potent, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 86 nM and an NMDA receptor antagonist targeting the GluN1-1b/GluN2B subunit combination with an IC50 of 3.876 μM... | |||
T4364 | Aftin-4 | Aftin 4,Aftin4 | Beta Amyloid , Gamma-secretase |
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus... | |||
T77162 | Donanemab | ||
Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody targeting a pyroglutamate amyloid beta (Aβ) epitope at the N-terminus. It shows promise for research in early Alzheimer's disease [1] [2]. | |||
T22678 | 3,5-Bis(4-nitrophenoxy)benzoic acid | Compound W | Gamma-secretase |
3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). | |||
T3246 | Tabersonine | (-)-Tabersonine,Tabersonin | Others |
Tabersonine (Tabersonin)is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus. | |||
T2194 | Direct Blue 1 | Pontamine sky blue,Chicago Sky Blue 6B | GluR |
Direct Blue 1 (Pontamine sky blue), a counterstain for background autofluorescence in immunofluorescence histochemistry, structurally resembles glutamate and operates as a potent, competitive VGLUT inhibitor, not impacti... | |||
T3S0645 | N-trans-Feruloyltyramine | Feruloyltyramine,N-Feruloyltyramine,Moupinamide | Others , COX |
1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s... | |||
T10630 | BuChE-IN-TM-10 | TM-10 | AChR |
BuChE-IN-TM-10 (TM-10) is a potent inhibitor of butyrylcholinesterase (BuChE), exhibiting an IC50 of 8.9 nM. It effectively inhibits and disaggregates self-induced Aβ aggregation, displays significant antioxidant activit... | |||
T80622 | Trontinemab | ||
Trontinemab, a bispecific humanized IgG1-κ antibody, targets the amyloid beta A4 precursor protein (APP) and transferrin receptor p90, CD71 (TFRC). It is utilized in research on Alzheimer's disease (AD) [1] [2]. | |||
T24779 | SEN-1269 | ||
SEN-1269 is an amyloid-β (AB) aggregation inhibitor that acts by blocking Aβ(1-42) aggregation and protecting neuronal cell lines exposed to Aβ(1-42), reducing Aβ oligomer-induced LTP and memory deficits in vivo. | |||
T78885 | Aβ-IN-8 | ||
Aβ-IN-8, also known as compound 7e, is a potent inhibitor of Aβ aggregation [1]. | |||
T37370 | Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt) | ||
Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. It forms fibrils that react to thioflavin T and Congo red an... | |||
T78884 | Aβ-IN-7 | ||
Aβ-IN-7 (compound 5a) acts as a potent inhibitor of Aβ aggregation, stabilizing Aβ monomers at 50 μM concentration to prevent them from forming larger oligomers and delaying the nucleation phase. Comparative studies demo... | |||
T61178 | Aβ-IN-5 | ||
Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor that also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Furthermore, Aβ-IN-5 exhibits remarkable neuroprotective effec... | |||
T37369 | Amyloid-β (1-8, A2V) Peptide | Amyloid-β (1-8, A2V) Peptide | |
Amyloid-β (1-8, A2V) is a truncated form of amyloid-β (Aβ) that contains a valine to alanine substitution at position 2 of the Aβ numbering convention (Aβ A2V), which corresponds to position 673 of the amyloid precursor ... | |||
T78173 | Aβ/tau aggregation-IN-3 | ||
Aβ/tau aggregation-IN-3 is a potent inhibitor of amyloid protein aggregation, exhibiting an IC50 value of 0.85 µM in an Aβ-Thioflavin T (Aβ-ThT) functional aggregation assay. This compound demonstrates anti-amyloid activ... | |||
T78426 | MCAAD-3 | ||
MCAAD-3, a near-infrared Aβ imaging probe, exhibits blood-brain barrier permeability and strong affinity for Aβ polymers (Ki >106 nM). It successfully labels Aβ plaques in the brains of transgenic mice [1]. |