as-iv — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2973	Astragaloside IV	AST-IV,AS-IV	MMP , ERK , Estrogen/progestogen Receptor , JNK
	Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cel...		MMP , ERK , Estrogen/progestogen Receptor , JNK
TN2444	Batatasin IV		Others
	Batatasin IV is identified from Dioscorea opposita which is a a type of homologous medicinal plant and is commonly used as food in daily life.		Others
T13231L	Trovafloxacin mesylate		Others , DNA/RNA Synthesis , Topoisomerase , Antibacterial
	Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the ...		Others , DNA/RNA Synthesis , Topoisomerase , Antibacterial
T4042	Talabostat mesylate	Val-boroPro,PT100	Proteasome , DPP-4
	Talabostat mesylate (PT100) is an orally active, selective inhibitor of dipeptidyl peptidases IV (DPP4, IC50: 0.18 nM), including tumor-associated fibroblast activation protein. This agent may also stimulate the producti...		Proteasome , DPP-4
T8550	NDMC101		Others , NF-κB , Proteasome
	NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.		Others , NF-κB , Proteasome
T1492	Gemifloxacin mesylate	LB-20304a,SB-265805S,Gemifloxacin mesylate	DNA gyrase , Topoisomerase , Antibacterial
	Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. Gemifloxacin Mesylate is the mesylate salt form of...		DNA gyrase , Topoisomerase , Antibacterial
T7502	PF 05089771 tosylate		Sodium Channel
	PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8...		Sodium Channel
T0480	Doxofylline	Doxophylline	PDE , Adenosine Receptor
	Doxofylline (Doxophylline) is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with s...		PDE , Adenosine Receptor
T2S2215	Crebanine		Apoptosis , Others , Akt
	1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat...		Apoptosis , Others , Akt
T36466	Chlorin E6	Ce6,Chlorin e6,CE6	Parasite
	Chlorin E6 (CE6) is a second-generation photosensitizer with antitumor activity when used in combination with irradiation. In a mouse model of implanted fibrosarcoma, Chlorin E6 (2.5-10 mg/kg, i.v., 50-200 J/cm2 irradiat...		Parasite
T79911	O-Benzoylhydroxylamine
	O-Benzoyl hydroxylamine exhibits properties as a dipeptidyl peptidase-IV (DPP-IV) inhibitor and demonstrates antidiabetic effects[1].
T26242	SW IV-52	SW-IV-52,SW IV52,SW IV 52,SWIV52
	SW IV-52 is an XIAP-inhibitor that acts as a second mitochondria-derived activator of caspases (SMAC) mimetic.
T68423	Revamilast sodium
	Revamilast sodium, also known as GRC4039 sodium, is a phosphodiesterase IV inhibitor for potentially treating of asthma and rheumatoid arthritis
T61414	DPP-4 inhibitor 3
	Compound 5a, also known as DPP-4 inhibitor 3, is a powerful dipeptidyl peptidase IV (DPP-IV) inhibitor, demonstrating an IC50 value of 0.75 nM. It exhibits outstanding antioxidant and insulinotropic activity [1].
T30923	CI-1018	UNII-05127JZ9KQ
	CI-1018 is a PDE IV inhibitor that is being developed as a drug to suppress inflammation.
T68424	Revamilast
	Revamilast, also known as GRC4039, is a phosphodiesterase IV inhibitor for potentially treating of asthma and rheumatoid arthritis
T74810	Anti-MRSA agent 7
	Anti-MRSA agent 7 (Compound 12) serves as a potent antibacterial compound effectively inhibiting both S. aureus and E. coli DNA gyrases, as well as topo IV enzymes from the same organisms, with IC50 values of 0.185 μM, 0...
T62019	Sheng Gelieting
	Sheng Gelieting (CGT-8012) is a inhibitor of dipeptidy peptidase-IV enzyme (DP-IV) with an IC 50 value of 87 nM. Sheng Gelieting can be used for researching to the dipeptidy peptidase-IV enzyme, such as the diabetes, par...
T26963	CBR-2092	TNP2092,CBR2092,TNP-2092,TNP 2092
	CBR-2092 is a DNA-directed RNA polymerase and DNA topoisomerase inhibitor. CBR-2092 exhibited rifampin-like potency as an inhibitor of RNA polymerase, was an equipotent (balanced) inhibitor of DNA gyrase and DNA topoisom...
T21370	Amiodarone	Nexterone,Amiodarona,Cordarone,Aratac,Amiodaronum
	Amiodarone is categorized as a class III antiarrhythmic agent and prolongs phase 3 of the cardiac action potential. It also has numerous other effects, including actions that are similar to those of antiarrhythmic classe...