AS-IV

Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.

4-Vinylphenol is the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine found in Hedyotis diffusa Willd. 4-Vinylphenol induces apoptosis in vivo.

Myrcene is a terpene that has been found in Cannabis and has antioxidative properties.

α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.

Chlorin E6 (CE6) is a second-generation photosensitizer with antitumor activity when used in combination with irradiation. In a mouse model of implanted fibrosarcoma, Chlorin E6 (2.5-10 mg/kg, i.v., 50-200 J/cm2 irradiation) resulted in complete tumor disappearance after varying degrees of irradiation. Agents including Chlorin E6 were tested in a Phase I clinical study in patients with early superficial squamous cell carcinoma of bronchial origin with favorable results (40 mg/m2, IV, 100 J/cm2 laser irradiation). In a Phase II clinical trial in patients with early stage lung cancer, the same mode of administration resulted in a complete response in 82.9% of patients. Chlorin E6 has been investigated as a nanotechnology drug delivery tool.

Arvenin IV is a natural product that can be used as a reference standard. The CAS number of Arvenin IV is 69312-48-7.

Isochromophilone IV is a natural product that can be used as a reference standard. The CAS number of Isochromophilone IV is 167173-90-2.

1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rata. 2. Crebanine can also decrease t

Ginsenoside Ra6 is a rare and newly identified protopanaxadiol-type triterpene saponin isolated from Asian ginseng (Panax ginseng), distinguished by unique butenoyl and acetyl sugar modifications on the dammarane core structure that reduce polarity and define it as a Ra-type variant, making it a valuable compound for advanced pharmacological, metabolic, and natural product research investigations.

Astragaloside IV (Standard) is a reference standard for research and analysis in studies involving Astragaloside IV. Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.

Lo Han Kuo extract is a high intensive sweetening agent with desirable health benefits, such as prevention of dental caries through specific antibacterial properties, no-calorie levels related to obesity, and a low glycemic index to help manage blood suga

Picroside IV is an iridoid glycoside originating from the underground parts of Picrorhiza scrophulariiflora and serves as a derivative of Catalpol while demonstrating broad pharmacological functions including neuroprotective, hypoglycemic, anti-inflammatory, anticancer, antispasmodic, antioxidant, and anti-HBV effects. Picroside IV therefore represents a therapeutically valuable bioactive molecule with high relevance in disease prevention and treatment research.

Batatasin IV is identified from Dioscorea opposita which is a a type of homologous medicinal plant and is commonly used as food in daily life.

Kaempferol 3-O-alpha-L-(2, 3-di-Z-p-coumaroyl) rhamnoside (compound 42), a flavonol extracted from Platanus Occidentalis, functions as an inhibitor of alpha-amylase and DPP IV [1].

Demethylbatatasin IV is a naturally occurring compound found in the yam species known as Dioscorea alata.

Dactinomycin D (Actinomycin IV) is an antibiotic and autophagy activator produced by Streptomyces bacteria fermentation, which inhibits transcription and replication by inserting into the DNA double helix, and can also promote p53 phosphorylation and accumulation through MDM2 overexpression, serving as a chemotherapy drug for cancer treatment.