5-hete

5-HETE is a fatty acid metabolite and an oxidative derivative of arachidonic acid produced through lipoxygenase activity, existing as a racemic mixture of the 5(S)-HETE and 5(R)-HETE enantiomers, and it acts as a potent aggregating agent that induces the aggregation of human neutrophils with a IC50 value of approximately 200 nM.

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Astragalus polyphenols) is a compound isolated from the roots of Polygonum species, which inhibits the formation of 5-HETE, HHT, and thromboxane B2.

Astragalus polyphenols (Standard) is a reference standard for research and analysis in studies involving Astragalus polyphenols. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Astragalus polyphenols) is a compound isolated from the roots of Polygonum species, inhibits the formation of 5-HETE, HHT and thromboxane B2.

Magnolianin can inhibit strongly (IC50 = 0.45 uM) 5-HETE formation by die cytosol of guinea pig polymorphonuclear leukocytes.

Mulberrofuran A can inhibit the formations of 12-hydroxy-, 8, 10-heptadecatrienoic acid (HHT) and thromboxane B2, but it can increase the formation of 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid (12-HETE).

Hinokiol exhibits anti-inflammatory activity by significantly inhibiting 5-hydroxy-eicosa-tetra-enoic acid (5-HETE) and leukotriene B(4) (LTB4) formations. Additionally, it demonstrates potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).