2 pyrrolidinone

2-Pyrrolidinone is a characteristic compound present in cabbage. It is the lactam cyclization product of γ -aminobutyric acid (GABA) and has anti-cancer properties.

4-Phenyl-2-pyrrolidinone ,with CAS No. 1198-97-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Phenyl-2-pyrrolidinone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-(4'-Methoxyphenyl)-2-pyrrolidinone, with CAS No. 103859-86-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-(4'-Methoxyphenyl)-2-pyrrolidinone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5-Hydroxy-2-pyrrolidinone is a natural product of Buddleja, Loganiaceae. The catalog number is TN3117 and the CAS number is 62312-55-4. 5-Hydroxy-2-pyrrolidinone can be used as a reference standard.

N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone) is a five-membered cyclic amide and a widely used industrial organic polar solvent in the manufacture of adhesives, paints, fuels, and pharmaceuticals.

4-(3-Pyridinyl)-2-pyrrolidinone, with CAS No. 55656-99-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-(3-Pyridinyl)-2-pyrrolidinone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

L-Pyroglutamic Acid-D5 (Standard) is a reference standard of L-Pyroglutamic Acid-D5 intended for quantitative analysis, quality control, and related biochemical research applications. L-Pyroglutamic acid-d5 is the deuterated form of L-Pyroglutamic acid. The compound L-Pyroglutamic acid represents the levorotatory isomer of Pyroglutamic acid and is the biologically active enantiomer present in the human body. Pyroglutamic acid serves as an intermediate in the metabolism of glutathione.

1,5-Dimethyl-2-pyrrolidinone is a pyrrole derivative widely used in biochemical experiments and drug synthesis research.

Felipyrine is a derivative of 1-aryl-2-pyrrolidinone, known for its anti-inflammatory properties.

The prostaglandin E receptor 4 (EP4) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E2 . Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP, which plays important roles in bone formation and resorption, cancer, and atherosclerosis. KMN-80 is a substituted γ-lactam (pyrrolidinone) derivative of PGE1 that acts as a selective and potent agonist of EP4 with an IC50 value of 3 nM (IC50 = 1.4 μM for EP3 and > 10 μM for all other prostanoid receptors). In functional assays it has been shown to stimulate secreted alkaline phosphatase gene reporter activity in EP4-transfected HEK293 cells with an EC50 value of 0.19 nM, demonstrating >5,000 and 50,000-fold selectivity against EP2 and TP, respectively. KMN-80 can induce the differentiation of bone marrow stem cells from both young and aged rats into osteoblasts in vitro (EC50s = 20 and 153 nM, respectively) and exhibits favorable tolerability up to at least 10 μM, whereas the EP4 agonist L-902,688 is highly cytotoxic at similar concentrations in these cells. KMN-80 has been used to repair calvarial defects in an in vivo rat craniomaxillofacial reconstruction model (rate of reduction in defect size equivalent to BMP-2 treated rats) and to promote bone formation in a rat incisor tooth socket model.

(R)-(+)-Blebbistatin O-Benzoate is a derivative of Blebbistatin. (R)-(+)-Blebbistatin is a 1-phenyl-2-pyrrolidinone derivative and a selective inhibitor of non-muscle myosin II. It blocks cell blebbing rapidly and reversibly and also disrupts directed cell migration and cytokinesis in vertebrate cell. (R)-(+)-Blebbistatin can also inhibit contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. (R)-(+)-Blebbistatin is suitable as a negative control for (S)-(-)-Blebblastatin.

1-Methyl-2-pyrrolidon (Standard) is a reference standard of 1-Methyl-2-pyrrolidon intended for quantitative analysis, quality control, and related biochemical research applications.

ATG5-PPI Inhibitor 17b has a core structure of (E)-3-(2-furylmethylene)-2-pyrrolidinone and blocks the interactions between ATG5–ATG16L1 and ATG5–TECAIR in in vitro binding assays, with IC₅₀ values of 27.43 μM and 14.88 μM, respectively.

ATG5-PPI Inhibitor 17c has a core structure of (E)-3-(2-furylmethylene)-2-pyrrolidinone and blocks the interactions between ATG5–ATG16L1 and ATG5–TECAIR in in vitro binding assays, with IC₅₀ values of 12.78 μM and 12 μM, respectively.

ATG5-TECAIR Inhibitor 17f (IC₅₀ > 33 μM) has a core structure of (E)-3-(2-furylmethylene)-2-pyrrolidinone and blocks the interaction between ATG5 and ATG16L1 in in vitro binding assays.

4E1RCat analogue 2 has a core structure of (E)-3-(2-furylmethylene)-2-pyrrolidinone, and its analog 4E1RCat blocks the interactions between ATG5–ATG16L1 and ATG5–TECAIR in in vitro binding assays, with IC₅₀ values of 1.1 μM and 1.7 μM, respectively.

4E1rcat analogue 3 has a (E)-3-(2-furanylmethylene)-2-pyrrolidinone core structure, and its analog 4E1rcat blocks the interactions between ATG5-ATG16L1 and ATG5-TECAIR in in vitro binding assays with IC50 values of 1.1 μM and 1.7 μM, respectively.

4E1rcat analogue 5 possesses a core structure of (E)-3-(2-furanylmethylene)-2-pyrrolidinone. Its parent compound 4E1rcat blocks the interactions between ATG5-ATG16L1 and ATG5-TECAIR in in vitro binding assays, with IC₅₀ values of 1.1 μM and 1.7 μM, respectively.

4E1rcat 27d (Compound 27d) contains a core structure of (E)-3-(2-furanylmethylene)-2-pyrrolidinone. Its analog 4E1rcat blocks the interactions between ATG5-ATG16L1 and ATG5-TECAIR in in vitro binding assays, with IC₅₀ values of 1.1 μM and 1.7 μM, respectively.

4E1RCat analogue 8 has a core structure of (E)-3-(2-furylmethylene)-2-pyrrolidinone, and its analog 4E1RCat blocks the interactions between ATG5–ATG16L1 and ATG5–TECAIR in in vitro binding assays, with IC₅₀ values of 1.1 μM and 1.7 μM, respectively.

ATG5-PPI Inhibitor 12b possesses a core structure of (E)‑3‑(2‑furanylmethylene)‑2‑pyrrolidinone and blocks the interactions between ATG5‑ATG16L1 and ATG5‑TECAIR in in vitro binding assays, with IC₅₀ values of > 33 μM and 21.29 μM, respectively.