(s) thalidomide

(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-isomer of Thalidomide with immunomodulatory, anti-inflammatory, anticancer, anti-angiogenic, and pro-apoptotic activities, used in studying leprosy erythema nodosum and myeloma.

(S)-Deoxy-thalidomide functions as a ligand for E3 ubiquitin ligases. It is linked to target protein ligands via a linker, forming PROTACK-Ras Degrader-3. This compound specifically targets and degrades mutant KRAS proteins.

(S)-Deoxy-thalidomide-Br is a ligand for E3 ligase, utilized in the synthesis of PROTACFHD-609.

(S)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 is a conjugate that serves as both an E3 ubiquitin ligase ligand and a linker for NX-2127.

(S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-C-Pip is a conjugate of an E3 ubiquitin ligase ligand and a linker, employed in the synthesis of PROTACFHD-609.

Thalidomide-piperazine-(S)-CH2-pyrrolidine-C2-O-CH2-COO-C(CH3)3 is a synthetic ligand-linker conjugate for E3 ligase. It features a Thalidomide-based cereblon ligand and a linker. This compound can be utilized in the synthesis of PROTAC BET degraders.

(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3 is an E3 ligase ligand-linker conjugate (E3LigaseLigand-Linker Conjugates) composed of thalidomide and its corresponding linker. This compound functions as a Cereblon ligand, facilitating the recruitment of CRBN protein, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.

(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH is a conjugate combining an E3 ligase ligand with a linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding Linker. This compound functions as a Cereblon ligand, recruiting the CRBN protein and serving as a crucial intermediate in the synthesis of complete PROTAC molecules.

(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), consisting of Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit the CRBN protein and serves as a crucial intermediate for synthesizing complete PROTAC molecules.

(S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit CRBN protein and serves as a crucial intermediate for synthesizing complete PROTACs molecules.

Compound C63 (S)-Thalidomide-NH-cyclohexane-NH-Ph-NH2 is an E3 ligase plus linker for PROTAC, comprising a cereblon ligand based on Thalidomide and one linker, suitable for PROTAC synthesis.

E3ligaseLigand-Linker Conjugate 30 is a compound made by conjugating an E3 ligase ligand, Thalidomide, with a linker. This conjugate functions as a Cereblon ligand to recruit CRBN protein and serves as a crucial intermediate in the synthesis of complete PROTACs molecules.

PROTAC ER Degrader-14 (compound 86) is a PROTAC-type estrogen receptor ERR degrader. It comprises an E3 ubiquitin ligase ligand (blue part) (S)-Deoxy-thalidomide, a PROTAC linker (black part) N-Boc-piperazine, and a target protein ligand (red part) ER ligand-6. The combination of the E3 ligase and linker forms tert-Butyl (S)-4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperazine-1-carboxylate.

JB170 is a highly efficient and specific Aurora A degradator (DC50 = 28 nM). The PROTAC is composed of Alisertib and Thalidomide, with an EC50 value for AURORA-A that is ten times that of AURORA-B. It induces S-phase arrest in cell growth and inhibits the non-catalytic function of the AURORA-A kinase.

Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).