Physalis

WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or cancer.

Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by Human T-lymphotropic virus type 1 (HTLV-1) infection

Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.

2,3-Didehydrosomnifericin is a compound isolated from Pteris oleifera, a plant of the Solanaceae family.

Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammatory eczema and herpes, among other diseases.Physalin B ameliorates lipopolysaccharide-induced inflammatory response due to acute lung injury by inhibiting NF-κB and NLRP3 through activation of the PI3K/Akt pathway.Physalin B inhibits PDGF-BB-induced VSMC proliferation and migration and phenotypic transformation through activation of the Nrf2 pathway. Physalin B inhibits PDGF-BB-induced VSMC proliferation, migration and phenotypic transformation through activation of the Nrf2 pathway.Physalin B exerts antitumor activity by inhibiting LAP2α-HDAC1-mediated deacetylation of glioma-associated oncogene 1 and hepatic stellate cell activation.

Dihydrowithaferin A is a withanolide isolated from Withania somnifera with activity against acetylcholinesterase (AChE). Dihydrowithaferin A in the diet may prevent or decrease the growth of tumors.

Physalin A is an anti-inflammatory compound isolated from P. alkekengi with anti-fibrotic effects, regulating the Nrf2 pathway through ERK and p38 to induce detoxification enzymes. Physalin A blocks the activation of the NF-kappaB signaling pathway. Physalin A reduces mammosphere formation by reducing the expression of the GLI1 gene and the YAP1 gene.

Physalin O, a physalin compound isolated from Physalis angulata, exhibits cytotoxicity against Hep G2 and MCF-7 cancer cells (IC50 values of 31.1 and 11.4 μM, respectively). This compound inhibits nitric oxide (NO) production and demonstrates anti-inflammatory activity.

Withanolide C is a natural product from Physali alkekengi.

Isophysalin A exhibits anti-inflammatory activitiy, it exhibits conjugating abilities with glutathione and also shows significant nitric oxide (NO) production inhibiting activities.

Somnifericin is a natural product for research related to life sciences. The catalog number is TN6535 and the CAS number is 173693-57-7.

Physalin C, a natural product derived from Physalis alkekengi, is classified as a secosteriod [seco-16,17]. It displays a yellow powder form and has a molecular formula of C28H36O10. This compound is notable for its multiple bioactivities, including anticancer, antifungal, and antiviral effects.

Physalin L is a natural product,it shows a distinct fluorescence spot under UV 365 nm with good separation.

2,3-Dihydro-3-methoxywithaferin A is a natural withanolide that exhibits cytotoxicity to human cancer cells and serves as a potential anticancer compound. Additionally, it protects normal cells against stress.

7-Epi-5-eudesmene-1beta,11-diol is a natural product for research related to life sciences. The catalog number is TN3224 and the CAS number is 87261-77-6.

4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it affects alternative splicing by mo

Withanolide S is a natural product for research related to life sciences. The catalog number is TN5258 and the CAS number is 63139-16-2.

Physalin D shows antimalarial activity; it also exhibits a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H(37)Rv strain of 32 microg/mL. Physalin D displays considerable cytotoxicity against several cancer cell lines. It

Physapruin A is a natural product from Physalis pruinosa.

3-Eudesmene-1beta,11-diol is a natural product for research related to life sciences. The catalog number is TN2933 and the CAS number is 658062-22-7.

Phyperunolide E is a natural product from Physalis peruviana L.

Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both

Physalin G has antinociceptive property.

12-Deoxywithastramonolide is a natural product for research related to life sciences. The catalog number is TN3481 and the CAS number is 60124-17-6.