(-)-Sparteine ((-)-Lupinidine) is a quinolizidine alkaloid extracted from lupine, which is a voltage-gated sodium channel (VGSC) blocker with anticonvulsant activity.
(-)-Sparteine sulfate pentahydrate ((-)-Sparteine Sulfate) is a class 1a antiarrhythmic agent and sodium channel blocker capable of chelating bivalent calcium and magnesium.
β-Sparteine is a class 1a antiarrhythmic agent that functions as a voltage-gated sodium channel blocker. its deficient debrisoquine hydroxylation phenotype is attributed to the absence of cytochrome P-450IID1 protein in the livers of poor metabolizers, providing a classical pharmacogenetic model for studying interindividual variability in drug metabolism.
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism. Dalbergioidin protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway, suggests that it may be useful in bone metabolism diseases, particularly osteoporosis. Dalbergioidin also ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway.