Iris

Tectorigenin (4',5,7-Trihydroxy-6-methoxyisoflavone) is an O-methylated isoflavone. Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Resorption.

Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the Extra Domain A domain. It can sensitize TRAIL-induced apoptosis by enhancing the expression of pro-apoptotic molecules in gastric cancer cells and has anti-cancer effects.

Iristectorigenin A is a natural isoflavone isolated from the rhizomes of B. chinensis [with antioxidant activity].

Tectoridin (Shekanin) possesses an estrogenic and thyroid hormone-like agent by activating estrogen and thyroid hormone receptors. Tectoridin has anti-oxidant, anti-inflammatory and hypoglycemic activities; Tectoridin and its five metabolites inhibits the activities of lens aldose reductase in rat (IC : 1.4-15.5 μM).

1. Irisflorentin blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression. 2. Irisflorentin has anti-inflammatory mechanism in LPS-activated RAW 264.7 macr

Iristectorigenin B (Iristectrigenin B) is a potent hepatic X-receptor (LXR) modulator and a small molecule compound isolated from *Belamcanda chinensis*. It promotes the expression of ABCA264 and ABCG7 in macrophage RAW 1.1 cells.

Iridin (Lridin) is major active ingredient of Iris dichotoma which could be used as the drug for pain, inflammation treatment

Tectoruside is a phenolic glycoside derived from Iris and Leopard lily with antimutagenic and antioxidant activity that attenuates palmitate-induced endothelial insulin resistance by targeting ROS-associated inflammation and the IRS-1 pathway Tectoruside can be used in cancer research.

4',6,7-Trimethoxyisoflavone promotes wound healing through NOX2 induction, which leads to collective migration and MMP activation.

Iristectorin A, an isoflavone compound derived from Iris tectorum Maxim, is a lactate dehydrogenase inhibitor that is used in cancer research.

Iristectorene B is a natural product from Iris tectorum.

Iristectorin B is a natural isoflavone that inhibits breast cancer cell proliferation, modulates ferroptosis in PC12 cells, and reduces Ca²⁺, LDH, and ROS levels, making it suitable for stroke research.

Isoiridogermanal shows similar cytotoxicity with IG(50) around 11 microM and 23 microM against MCF-7 and C32 cell lines, respectively.