Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response and has antioxidant properties. Potent neuroprotective effects with a favorable therapeutic time
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can reduce MMP and inflammatory cytokine expression and increase moisturizing factors and antioxidant genes level, result in preventing wrinkle formation.
Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation. Phillyrin(Forsythin) may be a new preventive agent of acute lung injury in the clinical setting, it potentially contributes to the suppression of the activation of MAPK and NF-κB pathways, it also has protective effects on H2O2-induced oxidative stress and apoptosis in PC12 cells.
Forsythiaside A (Forsythiaside) has antimicrobial, anticomplementary, anti-inflammatory and antiendotoxin activities. Forsythiaside A inhibits Infected cells was confirmed by infecting primary chicken embryo kidney cells.
Skimmin (Skimmine) has anti-inflammatory activity, can significantly improve renal function and suppress the IgG deposition as well as the development of glomerular lesions in a rat model of membranous glomerulonephritis.
Febrifugine is an effective coccidiostat, possesses schizonticide props; it and its derivatives shows high degree of antimalarial activity but use limited by toxicity .
(3R)-Hydrangenol 8-O-glucoside pentaacetate is a natural product for research related to life sciences. The catalog number is TN2991 and the CAS number is 113270-98-7.
(3S)-Hydrangenol 8-O-glucoside pentaacetate is a natural product for research related to life sciences. The catalog number is TN2993 and the CAS number is 113270-99-8.
Hydrangenoside A dimethyl acetal is a natural product of Hydrangea, Saxifragaceae. The catalog number is TN4235 and the CAS number is 952485-00-6. Hydrangenoside A dimethyl acetal can be used as a reference standard.