Filipendula

Spiraeoside (Quercetin 4′-O-glucoside) is a compound that can be extracted from red onion skins. It exhibits antioxidant, anti-allergy, anti-inflammatory, and anti-tumor activities. It protects human myocardial cells from high glucose-induced damage, oxidative stress, and apoptosis by activating the PI3K/Akt/Nrf2 pathway. It also inhibits mast cell activation and IgE-mediated allergic reactions by suppressing phospholipase C-γ-mediated signaling.