Daphne

Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-inflammatory activities.

Yuankanin, a natural compound found in thyme leaves, Daphne gnidium and Daphne feddei, is a genkwanin-5-bioside with anthelmintic activity.

Rose oxide is a pyran derivative widely used in biochemical experiments and drug synthesis research.

Hydrangetin (7-Hydroxy-8-methoxycoumarin) is a small molecule compound from Daphne papyracea var that inhibits platelet aggregation.

1-Octadecene is a long-chain alkene widely used in biochemical experiments and drug synthesis research.

(RS)-Sakuranetin is the racemic form of Sakuranetin, exhibiting μM-level antagonism toward adenosine receptors and inhibitory effects on KB and P-388 cells.

Daphneticin is a new compound from Daphne odora Thunb. var. marginata, a plant belonging to the genus Daphne in the family Thymelaeaceae that have potential in studying cardiovascular disease. Daphneticin is additionally applicable in cardiovascular-related molecular research models for investigating plant-derived small molecule effects on vascular-associated signaling pathways and for exploratory bioactivity profiling in cardiac cellular systems.

Tiliroside (Standard) is a reference standard for research and analytical applications involving Tiliroside. Tiliroside (Tribuloside) exhibits anticarcinogenic activity. Tiliroside demonstrates hepatoprotective activity. Tiliroside exhibits antioxidant and anti-inflammatory activity and can inhibit neuroinflammation in neurodegenerative disorder models. Tiliroside demonstrates anti-diabetic effects that are at least partially mediated through inhibitory effects on carbohydrate digestion and glucose uptake in the gastrointestinal tract. Tiliroside and gnaphaliin function as antioxidants against in vitro Cu(2+)-induced LDL oxidation in the same order of magnitude compared with the reference compound probucol. Tiliroside enhances fatty acid oxidation through enhancement of adiponectin signaling associated with activation of both AMP-activated protein kinase and peroxisome proliferator-activated receptor α and ameliorates obesity-induced metabolic disorders. Tiliroside (Standard) is therefore extensively applicable to metabolic, oxidative stress, inflammation, and natural product-based biomedical research.

(+)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity against platelet aggregation with IC50 values of 108.5 and 90.02 uM, respectively. (+)-Acuminatin, and machilin G show dose-dependent potent inhibitory activities against PLCgamma1 in vitro with IC50 values ranging from 8.8 to 26.0 microM, the inhibition of PLCgamma1 may be an important mechanism for an antiproliferative effect on the human cancer cells, therefore, these inhibitors may be utilized as cancer chemotherapeutic and chemopreventive agents.

Daphnin is a natural product isolated from Daphne tangutica Maxim that exhibits inhibitory effects on HepG2 and Hep3B cells.

Yuanhuanin is a natural product for research related to life sciences. The catalog number is TN6573 and the CAS number is 83133-14-6.

Ethyl linolenate is a fatty acid ethyl ester that exhibits anti-melanogenic properties by suppressing cellular melanin synthesis with an IC50 of 70 μM.Ethyl linolenate inhibit forskolin-stimulated melanogenesis and reduces tyrosinase enzymatic activity. Its antimelanogenic profile supports the utilization of Ethyl linolenate in pigmentation disorder research and skin-lightening mechanism studies.

(2-oxochromen-7-yl) acetate, commonly known as 7-acetoxycoumarin or 7-acetyloxy-2H-1-benzopyran-2-one, is an organic chemical derivative of coumarin. (2-oxochromen-7-yl) acetate is additionally relevant in molecular biology research for studying coumarin derivative reactivity and for fluorescent probe development in biochemical and cellular analytical systems.

(+)-3-Hydroxy-1,5-diphenyl-1-pentanone exhibits both immunomodulatory and anti-tumor activity.