Yohimbine hydrochloride is a plant-derived alkaloid with alpha-2 adrenergic receptor blocking activity. By blocking presynaptic or postsynaptic alpha-2 adrenergic receptors, it promotes the release of norepinephrine and dopamine. It has been used in studies related to mydriasis and erectile dysfunction and is commonly used to induce hypertension models.

Alpha-Yohimbine is a 5-HT1A receptor agonist, it is strong selective 2-adrenoceptor antagonist. Alpha-Yohimbine possess aphrodisiac effect.