Mogroside IIe is a bitter triterpenoid saponin which is the main component of unripe Luo Han Guo fruit and a precursor of the commercially available sweetener mogroside V.
Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.
Grosvenorine (Grosvenorin) exhibits good antibacterial and antioxidant activities, with its metabolites possessing more potent activities, intestinal bacteria play an important role in the gastrointestinal metabolism of grosvenorine and significantly affect its pharmacological activities.
Mogroside IIA1 (Mogroside II-A1) is isolated from the fruits of Siraitia grosvenorii. Mogroside IIA1 is a a nonsugar sweetener and sweeter than sucrose. Mogroside IIA1 possesses antioxidant, antidiabetic and anticancer activities.
Mogroside III-E, a cucurbitane-type compound isolated from Siraitia grosvenorii, exhibits anti-inflammatory activity by attenuating LPS-induced acute lung injury in mice through the regulation of the TLR4/MAPK/NF-κB axis via AMPK activation. Additionally, it demonstrates anti-fibrotic activity by reducing pulmonary fibrosis through Toll-Like receptor 4 pathways.
Mogroside III, a triterpenoid glycoside and nonsugar sweetener, is transformed by human intestinal bacteria to release secondary glycoside (mogroside IIA1) and aglycone [mogrol].
Mogroside III-A2 exhibits inhibitory effects with IC50 values of 346-400 mol ratio 32 pmol TPA. and shows weak inhibitory effects on activation of (+ -)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor.
Lo Han Kuo extract is a high intensive sweetening agent with desirable health benefits, such as prevention of dental caries through specific antibacterial properties, no-calorie levels related to obesity, and a low glycemic index to help manage blood suga
11-Oxomogroside IV, a natural product, is a triterpenoid glycoside found in the fruit of Siraitia grosvenorii (Monk fruit). It exhibits significant biochemical properties and is often studied for its potential health benefits and applications in sweetening due to its low-caloric content. [1-(a-L-Arabinopyranosyl)-2-[b-D-glucopyranosyl-(1->2)-b-D-glucopyranosyl)-oxomogroside].
3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle, acting as a potent activator of AMPK and enhancing AMPK phosphorylation.
11-Oxomogroside IIa is a cucurbitane glycoside extracted from the fruits of Siraitia grosVenorii. It has inhibitory effects against the EBV-EA activation induced by TPA, shows weak inhibitory effects on activation of NOR 1, a nitric oxide (NO) donor.