Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory activity.

anticancer

Gynostemma Extract (Gypenoside IX) is a saponins extract derived from the Gynostemma pentaphyllum.

Gynosaponin I is a natural product from Gynostemma pentaphyllum.

Damulin A is an active dammarane-type saponin isolated from Gynostemma pentaphyllum and belongs to a group of structurally related compounds whose anticancer structure–activity relationships have been deeply explored. Comparative investigations reveal that double bonds positioned at C20(21) and C20(22) and hydroxyl modification at C-2 significantly contribute to cytotoxicity, as evidenced by proliferation inhibition in A549 cells. These findings confirm the importance of Damulin A within the broader context of Gynostemma-derived anticancer leads.

Gypenoside XIII is a Gynostemma pentaphyllum-derived gypenoside that exhibits pharmacological actions consistent with its structural class, including anti-Alzheimer’s disease, anticancer, and anti-atherogenic activities, supporting its emerging significance as a multifunctional natural compound with broad therapeutic potential for neurodegenerative and systemic disorders.

Yixingensin is a natural product for research related to life sciences. The catalog number is TN5458 and the CAS number is 158642-42-3.

Gylongiposide I is a natural triterpenoid saponin capable of inhibiting HIF-1α mRNA expression.

Gypenoside LI possesses non-small cell lung carcinoma A549 cell inhibitory activity.