1. Senkyunolide I has neuroprotective effect, associated with its anti-oxidation and anti-apoptosis properties.

Senkyunolide A is a natural product isolated from Ligusticum chuanxiong Hort, with anti-tumor activity.

Butylphthalide (3-Butylphthalide) is an anti-cerebral-ischemia drug; first isolated from the seeds of Apium graveolens Linn.

Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance and downregulates P-glycoprotein.

Ligustrazine (Tetramethylpyrazine), a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) shows anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.

Perlolyrine (Tribulusterine) is a naturally occurring alkaloid with molecular docking capacity (-5.73 to -6.59 kJ mol) with MAPK1, MAPK14, and SRC, with potential anticancer and anti-inflammatory effects.

Isopropyl ferulate is a natural product

Kaempferol-3-O-α±-D-arabinoside displays cytotoxic and high antioxidant activity.Kaempferol-3-O-arabinoside and kaempferol-3-O-glucoside can function as antioxidants in biological systems, particularly skin exposed to UV radiation by scavenging ROS, and protect cellular membrane against ROS; they can be applicable to new cosmeceuticals for antioxidant, antiaging, and antibacterial activity.

Senkyunolide G and senkyunolide I could serve as pharmacokinetic markers for sepsis care.