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Thyroid hormone receptor(THR)

The thyroid hormone receptor (TR) is a type of nuclear receptor that is activated by binding thyroid hormone.TRs act as transcription factors, ultimately affecting the regulation of gene transcription and translation. These receptors also have non-genomic effects that lead to second messenger activation, and corresponding cellular response.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T29011 Triiodothyronine Sulfate 31135-55-4
Triiodothyronine Sulfate
Triiodothyronine Sulfate is a prodrug to the Conventional Hormone Therapy of Hypothyroidism. Triiodothyronine sulfate is the main metabolite of thyroid hormone t...
T25455L Glutaurine aceate T25455L 98%
Glutaurine aceate
Glutaurine aceate containing glutamine and taurine residues is an orally active hormone of the parathyroid. Glutaurine aceate, as a hormone, is isolated from par...
T15699 L-Thyroxine sodium salt pentahydrate 6106-07-6 98%
L-Thyroxine sodium salt pentahydrate
L-Thyroxine sodium salt pentahydrate (Levothyroxine) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid h...
T15644 KAT681 373641-87-3 98%
KAT681
KAT681 is a liver selective thyromimetic.
T7590 Taltirelin 103300-74-9 98%
Taltirelin
Taltirelin (TA-0910) is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic...
T1309 Propylthiouracil 51-52-5 99.94%
Propylthiouracil
Propylthiouracil (6-n-Propylthiouracil) is a thyroid peroxidase inhibitor and also a 5' -deiodinase inhibitor.
T22355 L-Thyroxine sodium 55-03-8 99.56%
L-Thyroxine sodium
L-Thyroxine sodium (LT4 sodium), the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.
T4461 3,5-Diiodo-L-thyronine 1041-01-6 99.49%
3,5-Diiodo-L-thyronine
3,5-Diiodo-L-thyronine (Diiodothyronine) is an iodinated thyronine hormone that regulates gene activity affecting processes such as homeostasis, lipid metabolism...
T13492 3,5-Diiodothyropropionic acid 1158-10-7 99.35%
3,5-Diiodothyropropionic acid
3,5-Diiodothyropropionic acid (C082182) is a thyroid hormone analog. It induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (Ka: 2.40...
T1310 2-Thiouracil 141-90-2 99.33%
2-Thiouracil
2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.
T1653 Liothyronine 6893-02-3 99.28%
Liothyronine
Liothyronine (Tresitope) is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity.
T0952 Carbimazole 22232-54-8 99.22%
Carbimazole
Carbimazole (Athyromazole) is an Imidazolium thyroid antagonist, which is rapidly transformed into MMI in vivo and can be converted into methidazole in vitro, an...
T1604 Tiratricol 51-24-1 99.16%
Tiratricol
Tiratricol (3,3',5-Triiodothyroacetic acid) is a metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tir...
T3595 Resmetirom 920509-32-6 99.05%
Resmetirom
Resmetirom (VIA-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist.
T0864 L-Thyroxine 51-48-9 98.64%
L-Thyroxine
L-Thyroxine (NSC 36397) is the major hormone derived from the thyroid gland. L-Thyroxine (NSC 36397) is synthesized via the iodination of tyrosines (MONOIODOTYRO...
T23673 AH-3960 862907-48-0 98.44%
AH-3960
AH-3960 is an thyroid hormone receptor-1 (PTHR1) agonist.
T11101 DS08210767 2376334-75-5 98.33%
DS08210767
DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM.
T5313 Sobetirome 211110-63-3 98.25%
Sobetirome
Sobetirome (IACS-010759) is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).
T5360 Eprotirome 355129-15-6 98.25%
Eprotirome
Eprotirome (KB2115), a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist.
T16442 PCO371 1613373-33-3 98%
PCO371
PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimeth...
Triiodothyronine Sulfate
T29011
Triiodothyronine Sulfate is a prodrug to the Conventional Hormone Therapy of Hypothyroidism. Triiodothyronine sulfate is the main metabolite of thyroid hormone t...
Glutaurine aceate
T25455L
Glutaurine aceate containing glutamine and taurine residues is an orally active hormone of the parathyroid. Glutaurine aceate, as a hormone, is isolated from par...
L-Thyroxine sodium salt pentahydrate
T15699
L-Thyroxine sodium salt pentahydrate (Levothyroxine) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid h...
KAT681
T15644
KAT681 is a liver selective thyromimetic.
Taltirelin
T7590
Taltirelin (TA-0910) is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic...
Propylthiouracil
T1309
Propylthiouracil (6-n-Propylthiouracil) is a thyroid peroxidase inhibitor and also a 5' -deiodinase inhibitor.
L-Thyroxine sodium
T22355
L-Thyroxine sodium (LT4 sodium), the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.
3,5-Diiodo-L-thyronine
T4461
3,5-Diiodo-L-thyronine (Diiodothyronine) is an iodinated thyronine hormone that regulates gene activity affecting processes such as homeostasis, lipid metabolism...
3,5-Diiodothyropropionic acid
T13492
3,5-Diiodothyropropionic acid (C082182) is a thyroid hormone analog. It induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (Ka: 2.40...
2-Thiouracil
T1310
2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.
Liothyronine
T1653
Liothyronine (Tresitope) is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity.
Carbimazole
T0952
Carbimazole (Athyromazole) is an Imidazolium thyroid antagonist, which is rapidly transformed into MMI in vivo and can be converted into methidazole in vitro, an...
Tiratricol
T1604
Tiratricol (3,3',5-Triiodothyroacetic acid) is a metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tir...
Resmetirom
T3595
Resmetirom (VIA-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist.
L-Thyroxine
T0864
L-Thyroxine (NSC 36397) is the major hormone derived from the thyroid gland. L-Thyroxine (NSC 36397) is synthesized via the iodination of tyrosines (MONOIODOTYRO...
AH-3960
T23673
AH-3960 is an thyroid hormone receptor-1 (PTHR1) agonist.
DS08210767
T11101
DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM.
Sobetirome
T5313
Sobetirome (IACS-010759) is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).
Eprotirome
T5360
Eprotirome (KB2115), a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist.
PCO371
T16442
PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimeth...
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TargetMol