Phospholipase

A phospholipase is an enzyme that hydrolyzes phospholipids[1] into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C and D, which are distinguished by the type of reaction which they catalyze.

Cat. No.	Product name	CAS No.	Purity
T31929	Giripladib	865200-20-0	98%
T31929	Giripladib(PLX-695) is a cPLA2-specific inhibitor that inhibits the radiation-induced increase of phosphorylated ERK and phosphorylated Akt in endothelial cells....
T11874	Lp-PLA2-IN-3	2196245-16-4	98%
T11874	Lp-PLA2-IN-3 is a potent and orally bioactive lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor that inhibits recombinant human Lp-PLA2 with an IC50 va...
T77638	BIRM 271	149106-77-4	98%
T77638	BIRM 271 is a novel arachidonic acid release inhibitor that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils. BIRM 271 and ...
T11149	Ecopladib	381683-92-7	98%
T11149	Ecopladib is a sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α), with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays,...
T14829	Bromoenol lactone	88070-98-8	98%
T14829	Bromoenol lactone is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β; IC50: ~7 μM). It inhibits antigen...
T11873	Lp-PLA2-IN-2	2071636-15-0	98%
T11873	Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.
T11835	LCL521	1226851-11-1	98%
T11835	LCL521 inhibits lysosomal acid sphingomyelinase (ASMase).LCL521 is an acid ceramidase (ACDase) inhibitor.
TN3139	5α-Hydroxycostic acid	132185-83-2	98%
TN3139	5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
T9001	Desketoraloxifene	216570-81-9	98%
T9001	Desketoraloxifene is a selective estrogen receptor modulator, inhibiting mammalian PLD (PLD1 and PLD2).
T15948	MAFP	188404-10-6	98%
T15948	MAFP is an effective irreversible inhibitor of anandamide amidase. MAFP is an active-site directed and irreversible inhibitor of cPLA2 and iPLA2.
TN4247	Ikshusterol 3-O-glucoside	112137-81-2	98%
TN4247	Ikshusterol 3-O-glucoside has a potent snake-venom neutralizing capacity and it might be a potential molecule for the therapeutic treatment for snakebites.
T8968	ML299	1426916-00-8	98%
T8968	ML-299 is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).
TP1299	Melittin	20449-79-0	98%
TP1299	Melittin, a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity...
T21681	AACOCF3	149301-79-1	98%
T21681	AACOCF3 is a cell-permeable trifluoromethyl ketone analog of arachidonic acid. It is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phosph...
TN7075	Linocinnamarin	554-87-0	98%
TN7075	Linocinnamarin is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen-stimulated degranulation by LN is mainly due to inactivation of S...
T3616	Carbazochrome	69-81-8	98%
T3616	Carbazochrome is an antihemorrhagic, or hemostatic, agent that will cease blood flow by causing the aggregation and adhesion of platelets in the blood to form a ...
T8531	M-3M3FBS	200933-14-8	98%
T8531	m-3M3FBS is a phospholipase C (PLC) activator.
T0944	Levamisole hydrochloride	16595-80-5	98%
T0944	Levamisole hydrochloride is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by ...
T6529	Halobetasol propionate	66852-54-8	98%
T6529	Halobetasol Propionate is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activitie...
T0674	Lansoprazole	103577-45-3	98%
T0674	Lansoprazole is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug...