Phospholipase

A phospholipase is an enzyme that hydrolyzes phospholipids[1] into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C and D, which are distinguished by the type of reaction which they catalyze.

Cat No.	product name
T0188	Fluticasone propionate	Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist...
T0458	Indometacin	Indomethacin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.
T0693	Niflumic acid	Niflumic acid is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
T0942	Quinacrine dihydrochloride	Quinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
T0944	Levamisole hydrochloride	Levamisole hydrochloride is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by...
T2044	Varespladib	Varespladib, a specific and effective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor(IC50=7 nM), has been investigated for the treatment and...
T2282	RPI1	RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.
T2907	Tanshinone I	Tanshinone I, an active principle isolated from the herbal medicine Salvia miltiorrhiza, displays cytotoxicity against tumor cells.
T2938	(E/Z)-Polydatin	(E/Z)-Polydatin, is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchens...
T3417	Amentoflavone	Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in ...
T3580	FIPI	FIPI is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM); prevents PLD regulation of F-actin cytoskeleton reo...
T3616	Carbazochrome	Carbazochrome is an antihemorrhagic, or hemostatic, agent that will cease blood flow by causing the aggregation and adhesion of platelets in the blood to form ...
T3640	GW 4869	GW4869 is a noncompetitive inhibitor of neutral sphingomyelinase (N-SMase, IC50 of 1 μM). GW4869 is an exosome biogenesis/release inhibitor.
T3775	Armepavine	Armepavine exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBPß pathways. It improves experimental autoim...
T4192	hnps-PLA Inhibitor	Hnps-PLA Inhibitor is an inhibitor of human nonpancreatic secretory Phospholipase A (hnps-PLA).
T6109	Darapladib	Darapladib(IC50=0.25 nM) is a substituted pyrimidone with inhibitory activity towards lipoprotein-associated phospholipase-A2 (Lp-PLA2).
T6243	U73122	U73122, an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.
T6529	Halobetasol Propionate	Halobetasol Propionate is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activiti...
T4S0590	Columbin	1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RB...
T5454	ACA	N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker.
T7280	CAY10594	CAY10594 is a potent phospholipase D2(PLD2) inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JN...
TQ0105	CAY10650	CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).
TQ0159	U 73343	U-73122 is an inhibitor of PLC-dependent processes, however, the mechanism of action remains unclear.
T3439	ML348	ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM).
T14829	Bromoenol lactone	Bromoenol lactone is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β; IC50: ~7 μM). It inhibits anti...
T11149	Ecopladib	Ecopladib with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively.Ecopladib is a sub-micromolar inhibitor of cytosolic p...
T15949	Mahanimbine	Mahanimbine suppresses the progression of high-fat diet (HFD)-induced metabolic complications in mice. Mahanimbine is an orally active alkaloid from curry leave...
T16751	Rilapladib	Rilapladib is a selective Lipoprotein-Associated Phospholipase A2 inhibitor (IC50: 230 pM). Rilapladib is also a Platelet Activating Factor Receptor antagonist.
T11873	Lp-PLA2-IN-2	Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.
T17239	VU0155069	VU0155069 strongly inhibits the invasive migration of several cancer cell lines in transwell assays. VU0155069 is a selective phospholipase D1 inhibitor (IC50: ...
TP1299	Melittin	Melittin, a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activit...
TN3139	5alpha-Hydroxycostic acid	5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
TN4247	Ikshusterol 3-O-glucoside	Ikshusterol 3-O-glucoside has a potent snake-venom neutralizing capacity and it might be a potential molecule for the therapeutic treatment for snakebites.
T8531	m-3M3FBS	m-3M3FBS is a phospholipase C (PLC) activator.
T21969	ML-095 hydrochloride	ML095 hydrochloride is a specific placental alkaline phosphatase inhibitor. It inhibits PLAP, TNAP and IAP with IC50 of 2.1, >100 and 53 μM, respectively.
TP1299L	Melittin TFA(20449-79-0(free base))	Melittin TFA is a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the a...
TP1299L	Melittin TFA(20449-79-0(free base))	Melittin TFA is a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the a...
T13206	Tris(2,4-di-tert-butylphenyl)phosphate	Tris(2,4-di-tert-butylphenyl)phosphate is a natural compound isolated from Vitex negundo L. with anti-inflammatory activity.
T8966	ML298	ML298 is a potent, specific inhibitor of Phospholipase D2 (PLD2, IC50 of 355 nM).
T8968	ML-299	ML-299 is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).
T9001	Desketoraloxifene	Desketoraloxifene is a selective estrogen receptor modulator, inhibiting mammalian PLD (PLD1 and PLD2).