Phospholipase

A phospholipase is an enzyme that hydrolyzes phospholipids[1] into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C and D, which are distinguished by the type of reaction which they catalyze.

Cat. No.	Product name	CAS No.	Purity
T17239	VU0155069	1130067-06-9	98%
T17239	VU0155069 strongly inhibits the invasive migration of several cancer cell lines in transwell assays. VU0155069 is a selective phospholipase D1 inhibitor (IC50: 4...
T8968	ML299	1426916-00-8	98%
T8968	ML-299 is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).
T9001	Desketoraloxifene	216570-81-9	98%
T9001	Desketoraloxifene is a selective estrogen receptor modulator, inhibiting mammalian PLD (PLD1 and PLD2).
TN7075	Linocinnamarin	554-87-0	98%
TN7075	Linocinnamarin is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen-stimulated degranulation by LN is mainly due to inactivation of S...
T14829	Bromoenol lactone	88070-98-8	98%
T14829	Bromoenol lactone is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β; IC50: ~7 μM). It inhibits antigen...
T15948	MAFP	188404-10-6	98%
T15948	MAFP is an effective irreversible inhibitor of anandamide amidase. MAFP is an active-site directed and irreversible inhibitor of cPLA2 and iPLA2.
TN4247	Ikshusterol 3-O-glucoside	112137-81-2	98%
TN4247	Ikshusterol 3-O-glucoside has a potent snake-venom neutralizing capacity and it might be a potential molecule for the therapeutic treatment for snakebites.
TN3139	5α-Hydroxycostic acid	132185-83-2	98%
TN3139	5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
T11873	Lp-PLA2-IN-2	2071636-15-0	98%
T11873	Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.
T15949	Mahanimbine	21104-28-9	98%
T15949	Mahanimbine suppresses the progression of high-fat diet (HFD)-induced metabolic complications in mice. Mahanimbine is an orally active alkaloid from curry leaves...
TP1299	Melittin	20449-79-0	98%
TP1299	Melittin, a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity...
T11149	Ecopladib	381683-92-7	98%
T11149	Ecopladib with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively.Ecopladib is a sub-micromolar inhibitor of cytosolic phos...
T15782	Lp-PLA2-IN-1	1420367-28-7	98%
T15782	Lp-PLA2 -IN-1 suppresses Lp-PLA2 activity processes for their preparation. Lp-PLA2 -IN-1also inhibits to compositions containing them and to their use in the tre...
T9753	LEI110	2313525-90-3	98%
T9753	LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol h...
T13632	D-Erythro-dihydrosphingosine	764-22-7	98%
T13632	D-Erythro-dihydrosphingosine inhibits arachidonic acid release and cPLA2α activity.
T21777	VU0359595	1246303-14-9	98%
T21777	VU0359595 is a potent and selective pharmacological phospholipase D1 (PLD1) inhibitor with an IC50 of 3.7 nM. VU0359595 is >1700-fold selective for PLD1 over PLD...
T15461	Halopemide	59831-65-1	98%
T15461	Halopemide is a potent inhibitor of PLD (IC50 = 220 and 310 nM for human PLD1 and PLD2). Halopemid is an antagonist of dopamine receptors. Halopemid can be used ...
T21907	PACOCF3	141022-99-3	98%
T21907	PACOCF3 is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells.
T10115	3-Nitrocoumarin	28448-04-6	98%
T10115	3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLCγ) inhibitor.
T21606L	Anti-Inflammatory Peptide 1 Acetate	T21606L
T21606L	Anti-Inflammatory Peptide 1 Acetate (C45H82N12O14S2) possesses a potent anti-inflammatory activity in vivo and is a strong inhibitor of phospholipase A2 (PLA2), ...