Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent. |
GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO). |
Telotristat ethyl is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production. |
Fenclonine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). F...
GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism. |
||LPA2 antagonist 1
LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM). |
Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM. |
Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorptio...
Osilodrostat (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM). |
Tetrahydropapaverine, an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons. |
Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. |
(R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hy...
Nepicastat (SYN-117) HCl is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respec...
Sapropterin dihydrochloride is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU. |