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Hydroxylase

Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Hydroxylation is the first step in the oxidative degradation of organic compounds in air. It is extremely important in detoxification since hydroxylation converts lipophilic compounds into water-soluble (hydrophilic) products that are more readily removed by the kidneys or liver and excreted. Some drugs (for example, steroids) are activated or deactivated by hydroxylation.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T15778 LP-533401 945976-43-2 98%
LP-533401
LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut.
T16779 Rodatristat ethyl 1673571-51-1 98%
Rodatristat ethyl
Rodatristat ethyl (KAR5585) is a first-of-its-kind orally active and potent tryptophan hydroxylase 1 (TPH1) inhibitor that significantly reduces 5-hydroxytryptam...
T6356 (R)-Nepicastat HCl 195881-94-8 98%
(R)-Nepicastat HCl
(R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and hu...
T15786 LPA2 antagonist 1 1017606-66-4 98%
LPA2 antagonist 1
LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM).
T15426 GSK180 1799725-26-0 98%
GSK180
GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.
T11470 GSK 366 1953157-39-5 98%
GSK 366
GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).
T7117 Sapropterin dihydrochloride 69056-38-8 99.88%
Sapropterin dihydrochloride
Sapropterin dihydrochloride (6R-BH4 dihydrochloride) is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.
T6004 Tetrahydropapaverine hydrochloride 6429-04-5 99.83%
Tetrahydropapaverine hydrochloride
Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) , an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.
T6604 Nepicastat hydrochloride 170151-24-3 99.81%
Nepicastat hydrochloride
Nepicastat hydrochloride (RS-25560-197 hydrochloride) is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50...
T30615 Bupicomide 22632-06-0 99.76%
Bupicomide
Bupicomide is a dopamine beta hydroxylase inhibitor with antihypertensive and vasodilatory activity that reduces 14C-norepinephrine biosynthesis of 14C-dopamine ...
T0679 Ketoconazole 65277-42-1 99.62%
Ketoconazole
Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
T41274 P-Fluoro-L-phenylalanine 1132-68-9 99.53%
p-Fluoro-L-phenylalanine
p-Fluoro-L-phenylalanine is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to ...
T21506 Telotristat 1033805-28-5 99.49%
Telotristat
Telotristat is the active metabolite of LX1606(Telotristat etiprate), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor and shows potential ...
T14119 ACT-678689 1783256-96-1 99.45%
ACT-678689
ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
T6044 Telotristat Etiprate 1137608-69-5 99.21%
Telotristat Etiprate
Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
T4277 Osilodrostat 928134-65-0 99.10%
Osilodrostat
Osilodrostat (LCI699) (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).
T41143 PCPA methyl ester hydrochloride 14173-40-1 99.08%
pCPA methyl ester hydrochloride
pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pC...
T15124 Diethyl-pythiDC 1821370-70-0 98.87%
Diethyl-pythiDC
Diethyl-pythiDC is an collagen prolyl 4-hydroxylase inhibitor.
T1896 Ro 61-8048 199666-03-0 98.86%
Ro 61-8048
Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.
T1447 Fenclonine 7424-00-2 98.81%
Fenclonine
Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYP...
LP-533401
T15778
LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut.
Rodatristat ethyl
T16779
Rodatristat ethyl (KAR5585) is a first-of-its-kind orally active and potent tryptophan hydroxylase 1 (TPH1) inhibitor that significantly reduces 5-hydroxytryptam...
(R)-Nepicastat HCl
T6356
(R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and hu...
LPA2 antagonist 1
T15786
LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM).
GSK180
T15426
GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.
GSK 366
T11470
GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).
Sapropterin dihydrochloride
T7117
Sapropterin dihydrochloride (6R-BH4 dihydrochloride) is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.
Tetrahydropapaverine hydrochloride
T6004
Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) , an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.
Nepicastat hydrochloride
T6604
Nepicastat hydrochloride (RS-25560-197 hydrochloride) is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50...
Bupicomide
T30615
Bupicomide is a dopamine beta hydroxylase inhibitor with antihypertensive and vasodilatory activity that reduces 14C-norepinephrine biosynthesis of 14C-dopamine ...
Ketoconazole
T0679
Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
p-Fluoro-L-phenylalanine
T41274
p-Fluoro-L-phenylalanine is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to ...
Telotristat
T21506
Telotristat is the active metabolite of LX1606(Telotristat etiprate), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor and shows potential ...
ACT-678689
T14119
ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
Telotristat Etiprate
T6044
Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
Osilodrostat
T4277
Osilodrostat (LCI699) (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).
pCPA methyl ester hydrochloride
T41143
pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pC...
Diethyl-pythiDC
T15124
Diethyl-pythiDC is an collagen prolyl 4-hydroxylase inhibitor.
Ro 61-8048
T1896
Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.
Fenclonine
T1447
Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYP...
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TargetMol