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Hydroxylase

Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Hydroxylation is the first step in the oxidative degradation of organic compounds in air. It is extremely important in detoxification since hydroxylation converts lipophilic compounds into water-soluble (hydrophilic) products that are more readily removed by the kidneys or liver and excreted. Some drugs (for example, steroids) are activated or deactivated by hydroxylation.

  • Osilodrostat
    T4277928134-65-0
    Osilodrostat (LCI699) (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).
    • $43
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    TargetMol | Inhibitor Hot
  • Casein
    T839699000-71-9
    Casein is a milk protein with multiple roles in a novel drug delivery system that affects postprandial amino acid delivery in different ways through its intragastric coagulation properties.
    • $29
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  • Bupicomide
    T3061522632-06-0In house
    Bupicomide is a dopamine beta hydroxylase inhibitor with antihypertensive and vasodilatory activity that reduces 14C-norepinephrine biosynthesis of 14C-dopamine and can be used to study hypertension.
    • $293
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    TargetMol | Inhibitor Sale
  • Diethyl-pythiDC
    T151241821370-70-0In house
    Diethyl-pythiDC is an collagen prolyl 4-hydroxylase inhibitor.
    • $38
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  • p-Ethynylphenylalanine
    T10142278605-15-5In house
    p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine), a tryptophan hydroxylase (TPH) inhibitor, is competitive, effective, selective, and reversible, with a Ki of 32.6 μM.
    • $34
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  • Ketoconazole
    T067965277-42-1
    Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
    • $33
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    TargetMol | Citations Cited
  • Tetrahydropapaverine hydrochloride
    T60046429-04-5
    Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) , an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.
    • $64
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  • p-Fluoro-L-phenylalanine
    T412741132-68-9
    p-Fluoro-L-phenylalanine is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to the L-leucine specific receptor of Escherichia coli with an KD of 0.26 μM.
    • $29
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  • Fenclonine
    T14477424-00-2
    Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine(CP-10188) acts pharmacologically to deplete endogenous levels of serotonin.
    • $30
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  • (R)-Nepicastat HCl
    T6356195881-94-8
    (R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
    • $135
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  • Telotristat
    T215061033805-28-5
    Telotristat is the active metabolite of LX1606(Telotristat etiprate), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor and shows potential antiserotonergic activity.
    • $30
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  • Sapropterin dihydrochloride
    T711769056-38-8
    Sapropterin dihydrochloride (6R-BH4 dihydrochloride) is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.
    • $31
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  • p-Ethynylphenylalanine hydrochloride
    T10142L188640-63-3
    p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selectively and reversibly the biosynthesis of serotonin may contribute to the characterization of the role of serotonin in behavioral and physiological activities[1].
    • $30
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  • EWP 815
    T6121420231-01-0
    EWP 815 is a disulfiram analogue that functions as a powerful inhibitor of Ins(1,4) P 2 phosphatase, Ins(1,4,5) P 3 5-phosphatase, and dopamine β-hydroxylase activity [1] [2].
    • $68
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  • Ro 61-8048
    T1896199666-03-0
    Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.
    • $33
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  • Telotristat Etiprate
    T60441137608-69-5
    Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
    • $38
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  • GSK180
    T154261799725-26-0
    GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.
    • $86
    5 days
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  • pCPA methyl ester hydrochloride
    T4114314173-40-1
    pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pCPA methyl ester hydrochloride is permeable across the blood-brain barrier and reduces 5-HT central availability.
    • $45
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  • GSK 366
    T114701953157-39-5
    GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).
    • $2,420
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  • ACT-678689
    T141191783256-96-1
    ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
    • $129
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  • Nepicastat hydrochloride
    T6604170151-24-3
    Nepicastat hydrochloride (RS-25560-197 hydrochloride) is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respectively.The affinity of Nepicastat for twelve other enzymes and thirteen neurotransmitter receptors is negligible.
    • $52
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  • Telotristat ethyl
    T118971033805-22-9
    Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
    • $34
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  • LX-1031
    T15796945976-76-1
    LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.
    • $68
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  • LPA2 antagonist 1
    T157861017606-66-4
    LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM).
    • $590
    35 days
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  • Zamicastat
    T133831080028-80-3
    Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively).
    • $88
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  • Mildronate
    T326876144-81-5
    Mildronate (Meldonium) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.
    • $42
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  • LP-533401
    T15778945976-43-2
    LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut.
    • $770
    35 days
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  • Rodatristat ethyl
    T167791673571-51-1
    Rodatristat ethyl (KAR5585) is a first-of-its-kind orally active and potent tryptophan hydroxylase 1 (TPH1) inhibitor that significantly reduces 5-hydroxytryptamine (5-HT) levels and decreases pulmonary arterial hypertension (PAH) at low concentrations.
    • $2,390
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