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Factor Xa

Factor X, also known by the eponym Stuart–Prower factor, is an enzyme  of the coagulation cascade. It is a serine endopeptidase (protease group S1, PA clan). Factor X is synthesized in the liver and requires vitamin K for its synthesis.Factor X is activated, by hydrolysis, into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as intrinsic Tenase) and factor VII with its cofactor, tissue factor (a complex known as extrinsic Tenase ). It is therefore the first member of the final common pathway or thrombin pathway.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T78424 CH3OCO-D-CHA-Gly-Arg-pNA acetate 80895-10-9 98%
CH3OCO-D-CHA-Gly-Arg-pNA acetate
CH3OCO-D-CHA-Gly-Arg-pNA acetate serves as a chromogenic substrate for Factor Xa, as documented in sources [1] [2].
T79847 Frunexian 1803270-60-1 98%
Frunexian
Frunexian (EP-7041) is a selective and potent inhibitor of coagulation factor XI/activated factor XI, specifically targeting XIa. It demonstrates antithrombotic ...
T80095 D-Pro-Phe-Arg-Chloromethylketone 88546-74-1 98%
D-Pro-Phe-Arg-Chloromethylketone
D-Pro-Phe-Arg-Chloromethylketone, an inhibitor of coagulation factor XII and plasma kallikrein, is significant in the regulation of thrombosis and inflammation [...
T82585 Denecimig 2488745-86-2 98%
Denecimig
Denecimig (Mim8), a novel bispecific human antibody mimetic of activated coagulation factor VIII, possesses both anti-FIXa and anti-FX arms. This compound robust...
T12736 Rivaroxaban-d4 1132681-38-9 98%
Rivaroxaban-d4
Rivaroxaban D4 is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent,selective and direct inhibitor of Factor Xa (FXa)(IC50:0.7 nM; Ki:0.4 nM).
T12782 RWJ-445167 226566-43-4 98%
RWJ-445167
RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
T19488 O-Desmethyl apixaban sulfate sodium 98%
O-Desmethyl apixaban sulfate sodium
O-Desmethyl apixaban sulfate sodium inhibits factor X (FXa) with a Ki of 58 μM,and is a major circulating metabolite of Apixaban in humans.
T77018 Garadacimab 2162134-62-3 SDS-PAGE:95% SEC-HPLC:99.99%
Garadacimab
Garadacimab (CSL312) is a potent whole-human IgG4 monoclonal antibody targeting activation factor XII (FXIIa). Garadacimab can be used to study hereditary angioe...
T6531 Heparin sodium salt 9041-08-1 BR
Heparin sodium salt
Heparin sodium is a sulfated polysaccharide, which belongs to the family of glycosaminoglycans. It is utilized as an anticoagulant and interacted with diverse pr...
T2368 Edoxaban Tosylate Monohydrate 1229194-11-9 99.97%
Edoxaban Tosylate Monohydrate
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
T0775 Coumarin 91-64-5 99.96%
Coumarin
Coumarin is a chemical compound/poison found in many plants, notably in high concentration in the tonka bean, woodruff, and bison grass. It has clinical value as...
T27920 LY 517717 313489-71-3 99.88%
LY 517717
LY 517717 is an orally active inhibitor of coagulation factor Xa with antithrombotic activity for the study of venous thromboembolism (VTE).
T31668 Eribaxaban 536748-46-6 99.74%
Eribaxaban
Eribaxaban (PD348292) is an orally available factor Xa inhibitor for the prevention and treatment of venous thromboembolism.
T1184 Rivaroxaban 366789-02-8 99.69%
Rivaroxaban
Rivaroxaban (BAY 59-7939) is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon ...
T0372 Gabexate mesylate 56974-61-9 99.64%
Gabexate mesylate
Gabexate mesylate (FOY) is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and...
T67853 Rivaroxaban Impurity 1151893-81-0 99.61%
Rivaroxaban Impurity
Rivaroxaban Impurity (Rivaroxaban-10) is a potent Blood-coagulation factor Xa inhibitor, IC50= 66 nM.
T2368L Edoxaban 480449-70-5 99.6%
Edoxaban
Edoxaban (Lixiana) (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K i s of 0.561 nM and 2.98 nM for free FXa and prothrombinase...
T0642 2-Methoxyphenothiazine 1771-18-2 99.56%
2-Methoxyphenothiazine
2-Methoxy Phenothiazine is light yellow or light gray solid.
T66256 Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 503614-91-3 99.55%
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate has an inhibitory effect on coagula...
T4690 Betrixaban hydrochloride(330942-05-7(free base)) 99.54%
Betrixaban hydrochloride(330942-05-7(free base))
Betrixaban hydrochloride(330942-05-7(free base)) (PRT054021 hydrochloride) is a potent, selective, and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM...
CH3OCO-D-CHA-Gly-Arg-pNA acetate
T78424
CH3OCO-D-CHA-Gly-Arg-pNA acetate serves as a chromogenic substrate for Factor Xa, as documented in sources [1] [2].
Frunexian
T79847
Frunexian (EP-7041) is a selective and potent inhibitor of coagulation factor XI/activated factor XI, specifically targeting XIa. It demonstrates antithrombotic ...
D-Pro-Phe-Arg-Chloromethylketone
T80095
D-Pro-Phe-Arg-Chloromethylketone, an inhibitor of coagulation factor XII and plasma kallikrein, is significant in the regulation of thrombosis and inflammation [...
Denecimig
T82585
Denecimig (Mim8), a novel bispecific human antibody mimetic of activated coagulation factor VIII, possesses both anti-FIXa and anti-FX arms. This compound robust...
Rivaroxaban-d4
T12736
Rivaroxaban D4 is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent,selective and direct inhibitor of Factor Xa (FXa)(IC50:0.7 nM; Ki:0.4 nM).
RWJ-445167
T12782
RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
O-Desmethyl apixaban sulfate sodium
T19488
O-Desmethyl apixaban sulfate sodium inhibits factor X (FXa) with a Ki of 58 μM,and is a major circulating metabolite of Apixaban in humans.
Garadacimab
T77018
Garadacimab (CSL312) is a potent whole-human IgG4 monoclonal antibody targeting activation factor XII (FXIIa). Garadacimab can be used to study hereditary angioe...
Heparin sodium salt
T6531
Heparin sodium is a sulfated polysaccharide, which belongs to the family of glycosaminoglycans. It is utilized as an anticoagulant and interacted with diverse pr...
Edoxaban Tosylate Monohydrate
T2368
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
Coumarin
T0775
Coumarin is a chemical compound/poison found in many plants, notably in high concentration in the tonka bean, woodruff, and bison grass. It has clinical value as...
LY 517717
T27920
LY 517717 is an orally active inhibitor of coagulation factor Xa with antithrombotic activity for the study of venous thromboembolism (VTE).
Eribaxaban
T31668
Eribaxaban (PD348292) is an orally available factor Xa inhibitor for the prevention and treatment of venous thromboembolism.
Rivaroxaban
T1184
Rivaroxaban (BAY 59-7939) is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon ...
Gabexate mesylate
T0372
Gabexate mesylate (FOY) is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and...
Rivaroxaban Impurity
T67853
Rivaroxaban Impurity (Rivaroxaban-10) is a potent Blood-coagulation factor Xa inhibitor, IC50= 66 nM.
Edoxaban
T2368L
Edoxaban (Lixiana) (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K i s of 0.561 nM and 2.98 nM for free FXa and prothrombinase...
2-Methoxyphenothiazine
T0642
2-Methoxy Phenothiazine is light yellow or light gray solid.
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
T66256
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate has an inhibitory effect on coagula...
Betrixaban hydrochloride(330942-05-7(free base))
T4690
Betrixaban hydrochloride(330942-05-7(free base)) (PRT054021 hydrochloride) is a potent, selective, and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM...
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TargetMol