DNA Methyltransferase

DNA methyltransferases are a group of enzymes involved in the regulation of gene expression. DNA methyltransferases cause the aberrant DNA methylation of tumor suppressor genes, which become hypermethylated and transcriptionally silent in some blood cancers.

Cat. No.	Product name	CAS No.	Purity
T16269	Nanaomycin A	52934-83-5	98%
T16269	Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 5...
T12790	Guadecitabine sodium	929904-85-8	98%
T12790	Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .
T17059	Tetrahydrouridine	18771-50-1	98%
T17059	Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator. It can be used in cancer treatment to make tumor cells more sensitive to radiation thera...
T19383	Isomaltotriose	3371-50-4	98%
T19383	Isomaltotriose is a sugar compound derived from the enzymic hydrolyzates of dextran obtained from the Leuconostoc mesenteroides NRRL B-512.
T10840	CM-579 trihydrochloride (1846570-40-8 free base)	T10840	98%
T10840	CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide ...
T15081	DC_517	500017-70-9	98%
T15081	DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).
T3606	γ-Oryzanol	11042-64-1	mixture
T3606	γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the ...
T15080	DC-05	890643-16-0	99.94%
T15080	DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).
T0192	Levetiracetam	102767-28-2	99.81%
T0192	Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizure...
T3717	Hinokitiol	499-44-5	99.78%
T3717	Hinokitiol (4-Isopropyltropolone) can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the a...
T2038	RG108	48208-26-0	99.78%
T2038	RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM).
TNU0425	2’-Deoxy-2’-fluoro-β-D-arabinocytidine hydrochloride	25183-22-6	99.69%
TNU0425	2’-Deoxy-2’-fluoro-β-D-arabinocytidine hydrochloride is a cytosine nucleoside analog with inhibitory effects on DNA methyltransferase , with potential antimetabo...
T1339	5-Azacytidine	320-67-2	99.62%
T1339	5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity. 5-Azacytidine regulates gene expression by decreasing ...
T10840L	CM-579	1846570-40-8	99.62%
T10840L	CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
T2495	Lomeguatrib	192441-08-0	99.62%
T2495	Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
T7718	5-Fluoro-2'-deoxycytidine	10356-76-0	99.5%
T7718	5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .
T26972	Cedazuridine	1141397-80-9	99.46%
T26972	Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.
T1904	SGI-1027	1020149-73-8	99.18%
T1904	SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027(SGI1027) against DNMT...
T1508	Decitabine	2353-33-5	99.17%
T1508	Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic a...
T24871	TFMB-(S)-2-HG	1445703-64-9	98.88%
T24871	TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase. Additionally, it significantly inhibits the EglN prolyl h...