T15081 |
DC_517
|
500017-70-9
|
98%
|
|
DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).
|
T10840 |
CM-579 trihydrochloride (1846570-40-8 free base)
|
T10840
|
98%
|
|
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide ...
|
T16287 |
Neurodazine
|
937807-66-4
|
98%
|
|
Neurodazine is an imidazole-based small molecule, serves as a promoter of neurogenesisin pluripotent cells. Neurodazine selectively inhibits astrocyte differenti...
|
T19383 |
Isomaltotriose
|
3371-50-4
|
98%
|
|
Isomaltotriose is a sugar from enzymic hydrolyzates of the dextran from Leuconostoc mesenteroides NRRL B-512.
|
T12790 |
Guadecitabine sodium
|
929904-85-8
|
98%
|
|
Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .
|
TNU0425 |
2’-Deoxy-2’-fluoro-beta-D-arabinocytidine hydrochloride
|
25183-22-6
|
98%
|
|
2’-Deoxy-2’-fluoro-beta-D-arabinocytidine hydrochloride is a cytosine nucleoside analog with inhibitory effects on DNA methyltransferase , with potential antimet...
|
T9573 |
GSK3685032
|
2170137-61-6
|
98%
|
|
GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DN...
|
T8967 |
SW155246
|
420092-79-1
|
98%
|
|
SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF...
|
T11469 |
GSK-3484862
|
2170136-65-7
|
98%
|
|
GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer.
|
T5198 |
Bobcat339
|
2280037-51-4
|
98%
|
|
Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
|
T7194 |
CM-272
|
1846570-31-7
|
98%
|
|
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
|
T3089 |
6-Thioguanine
|
154-42-7
|
98%
|
|
Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
|
T60322 |
Procainamide
|
51-06-9
|
98%
|
|
Procainamide is a specific and potent DNA methyltransferase 1 ( DNMT1 ) inhibitor. Procainamide is a Class 1A antiarrhythmic agent. Procainamide has the potentia...
|
T24871 |
TFMB-(S)-2-HG
|
1445703-64-9
|
98%
|
|
TFMB-(S)-2-HG is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase. Additionally, it significantly inhibits the EglN prolyl hydroxylases. W...
|
T2169 |
Zebularine
|
3690-10-6
|
98%
|
|
Zebularine is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. ...
|
T1904 |
SGI-1027
|
1020149-73-8
|
98%
|
|
SGI-1027 is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027 against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respec...
|
T26972 |
Cedazuridine
|
1141397-80-9
|
98%
|
|
Cedazuridine is an oral inhibitor of cytidine deaminase with antineoplastic properties.
|
T0018 |
Procainamide hydrochloride
|
614-39-1
|
98%
|
|
Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine...
|
T7840 |
2',3',5'-triacetyl-5-Azacytidine
|
10302-78-0
|
98%
|
|
2',3',5'-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.
|
T7718 |
5-Fluoro-2'-deoxycytidine
|
10356-76-0
|
98%
|
|
2'-DEOXY-5-FLUOROCYTIDINE is an inhibitor of DNA methyltransferase (DNMT) .
|