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CaMK

CAMK, also written as CaMK, is an abbreviation for the Ca2+/calmodulin-dependent protein kinase class of enzymes. CAMKs are activated by increases in the concentration of intracellular calcium ions (Ca2+) and calmodulin. When activated, the enzymes transfer phosphates from ATP to defined serine or threonine residues in other proteins, so they are serine/threonine-specific protein kinases. Activated CAMK is involved in the phosphorylation of transcription factors and therefore, in the regulation of expression of responding genes. CAMK also works to regulate the cell life cycle (i.e. programmed cell death), rearrangement of the cell's cytoskeletal network, and mechanisms involved in the learning and memory of an organism.There are 2 common types of CAM Kinase proteins: specialized and multi-functional CAM kinases.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T79718 CaMKIIα-PHOTAC 98%
CaMKIIα-PHOTAC
CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) that specifically targets Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). This molecule fa...
T80269 AC3-I, myristoylated 98%
AC3-I, myristoylated
Myristoylated AC3-I is a biologically active peptide and a myristoylated variant of the Autocamtide-3-Derived Inhibitory Peptide (AC3-I). It acts as a highly spe...
T80549 Calmodulin Kinase IINtide, Myristoylated 98%
Calmodulin Kinase IINtide, Myristoylated
Myristoylated Calmodulin Kinase IINtide (Myr-CaMKIINtide) serves as a selective and noncompetitive inhibitor of CaMKII [1].
T16752 Rimacalib 215174-50-8 98%
Rimacalib
Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).
T2606 KN-93 Phosphate 1913269-12-1 99.97%
KN-93 Phosphate
KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II with K i of 370 nM. KN-93 phosphate inhibits serum-induced fibrobla...
T2946 Tanshinone IIA sulfonate sodium 69659-80-9 99.9%
Tanshinone IIA sulfonate sodium
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent neg...
T23523 W-5 hydrochloride 61714-25-8 99.88%
W-5 hydrochloride
W-5 hydrochloride (N-(6-Aminohexyl)-1-naphthalenesulfonamide HCl) is a potent calmodulin antagonist.
T2697 KN-93 139298-40-1 99.86%
KN-93
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.
T1659 Melatonin 73-31-4 99.79%
Melatonin
Melatonin (Melatonine) is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in...
T14069 A-3 hydrochloride 78957-85-4 99.79%
A-3 hydrochloride
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and c...
T20792 W-7 hydrochloride 61714-27-0 99.75%
W-7 hydrochloride
W-7 hydrochloride (W-7 HCl), a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induc...
TP1403L Syntide 2 acetate(108334-68-5 free base) TP1403L 99.74%
Syntide 2 acetate(108334-68-5 free base)
Syntide-2 acetate is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 μM).
T68048 Cloxacepride 65569-29-1 99.72%
Cloxacepride
cloxacepride is a CaM antagonist that is used to treat asthma disease.
T8543 KN-92 hydrochloride 1431698-47-3 99.71%
KN-92 hydrochloride
KN-92 hydrochloride is an inactive derivative of KN-93. KN-93 is a selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor, competitively blocking CaM b...
T3S0807 Berbamine 478-61-5 99.64%
Berbamine
Berbamine is a natural product extracted from Phellodendron amurense. It acts as a calcium channel blocker and possesses anti-tumor, immunomodulatory, and cardio...
T0364 Dibucaine 85-79-0 99.64%
Dibucaine
Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.
TP1910L1 CALP1 acetate TP1910L1 99.63%
CALP1 acetate
CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 µM) that binds to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44....
T1090 Perphenazine 58-39-9 99.63%
Perphenazine
Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
T22538 A-7 hydrochloride 79127-24-5 99.54%
A-7 hydrochloride
A-7 hydrochloride is a calmodulin antagonist and causes alterations in the subpopulation of CD44+CD24- in MDA-MB-231 cells.
T13384L Y-33075 dihydrochloride 173897-44-4 99.43%
Y-33075 dihydrochloride
Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
CaMKIIα-PHOTAC
T79718
CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) that specifically targets Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). This molecule fa...
AC3-I, myristoylated
T80269
Myristoylated AC3-I is a biologically active peptide and a myristoylated variant of the Autocamtide-3-Derived Inhibitory Peptide (AC3-I). It acts as a highly spe...
Calmodulin Kinase IINtide, Myristoylated
T80549
Myristoylated Calmodulin Kinase IINtide (Myr-CaMKIINtide) serves as a selective and noncompetitive inhibitor of CaMKII [1].
Rimacalib
T16752
Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).
KN-93 Phosphate
T2606
KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II with K i of 370 nM. KN-93 phosphate inhibits serum-induced fibrobla...
Tanshinone IIA sulfonate sodium
T2946
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent neg...
W-5 hydrochloride
T23523
W-5 hydrochloride (N-(6-Aminohexyl)-1-naphthalenesulfonamide HCl) is a potent calmodulin antagonist.
KN-93
T2697
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.
Melatonin
T1659
Melatonin (Melatonine) is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in...
A-3 hydrochloride
T14069
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and c...
W-7 hydrochloride
T20792
W-7 hydrochloride (W-7 HCl), a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induc...
Syntide 2 acetate(108334-68-5 free base)
TP1403L
Syntide-2 acetate is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 μM).
Cloxacepride
T68048
cloxacepride is a CaM antagonist that is used to treat asthma disease.
KN-92 hydrochloride
T8543
KN-92 hydrochloride is an inactive derivative of KN-93. KN-93 is a selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor, competitively blocking CaM b...
Berbamine
T3S0807
Berbamine is a natural product extracted from Phellodendron amurense. It acts as a calcium channel blocker and possesses anti-tumor, immunomodulatory, and cardio...
Dibucaine
T0364
Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.
CALP1 acetate
TP1910L1
CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 µM) that binds to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44....
Perphenazine
T1090
Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
A-7 hydrochloride
T22538
A-7 hydrochloride is a calmodulin antagonist and causes alterations in the subpopulation of CD44+CD24- in MDA-MB-231 cells.
Y-33075 dihydrochloride
T13384L
Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
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TargetMol