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CaMK

CAMK, also written as CaMK, is an abbreviation for the Ca2+/calmodulin-dependent protein kinase class of enzymes. CAMKs are activated by increases in the concentration of intracellular calcium ions (Ca2+) and calmodulin. When activated, the enzymes transfer phosphates from ATP to defined serine or threonine residues in other proteins, so they are serine/threonine-specific protein kinases. Activated CAMK is involved in the phosphorylation of transcription factors and therefore, in the regulation of expression of responding genes. CAMK also works to regulate the cell life cycle (i.e. programmed cell death), rearrangement of the cell's cytoskeletal network, and mechanisms involved in the learning and memory of an organism.There are 2 common types of CAM Kinase proteins: specialized and multi-functional CAM kinases.

Calmodulin-Dependent Protein Kinase II 290-309 acetate
TP1271L
Calmodulin-Dependent Protein Kinase II 290-309 acetate is an effective antagonist of Ca2+ calmodulin-dependent protein kinase II (IC50 = 52 nM).
  • $133
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A-484954
TQ0137142557-61-7
A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.
  • $36
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Trifluoperazine
T8389117-89-5
Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
  • $41
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KN-93
T2697139298-40-1
KN-93 is a selective inhibitor of Ca2+ calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.
  • $52
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CaMKP Inhibitor
T215952789-62-5
CaMKP Inhibitor can inhibit CaMKP.
  • $35
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KN-93 Phosphate
T26061913269-12-1
KN-93 (Phosphate) can competitively block the binding of calmodulin to the corresponding kinase. It is a calcium calmodulin-dependent kinase II (CaMKII) inhibitor with a Ki of 370 nM. It can also inhibit the proliferation of human hepatic stellate cells.
  • $44
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Melatonin
T165973-31-4
Melatonin (Melatonine) is a natural hormone secreted by the pineal gland that activates melatonin receptors. Melatonin is a hormone that regulates the biological clock and also has antioxidant and anti-inflammatory activities.
  • $31
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Calmidazolium chloride
T1066757265-65-3
Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist with a Kd of 3 nM, which inhibits CaM-dependent phosphodiesterase (IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase (IC50 = 0.35 μM). It also induces apoptosis in certain cancer cell lines.
  • $57
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Nifedipine
T114621829-25-4
Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.
  • $45
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STO-609
T354652029-86-4
STO-609 is a specific and cell-permeable inhibitor of the Ca2+ calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα KKβ (Ki: 80 15 ng mL).
  • $35
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Tanshinone IIA sulfonate sodium
T294669659-80-9
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor P2X7. Tanshinone IIA sulfonate sodium (12.5 μM) inhibits hypoxia-induced PKG and PPAR-γ downregulation in PASMCs and distal pulmonary arteries of rats.
  • $39
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CaMKII-IN-1
T148601208123-85-6
CaMKII-IN-1, a potent and highly selective inhibitor of CaMKII (IC50 = 63 nM), exhibits over 100-fold higher selectivity for CaMKII compared to CaMKIV, MLCK, p38a, Akt1, and PKC.
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Psoralenoside
TN1008905954-17-8
Psoralenoside is a natural product isolated from the fruits of Psoralea corylifolia, shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.
  • $122
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Rottlerin
T1679182-08-6
Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation.
  • $35
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NH125
T6605278603-08-0
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
  • $34
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CALP1 acetate
TP1910L1
CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 µM) that binds to the CaM EF-hand Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) by inhibiting the open of calcium channel. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity.
  • $133
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Berbamine
T3S0807478-61-5
Berbamine is a natural product extracted from Phellodendron amurense. It acts as a calcium channel blocker and possesses anti-tumor, immunomodulatory, and cardiovascular effects.
  • $30
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KN-62
T2694127191-97-3
KN-62 is a potent and specific Ca2+ calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.
  • $30
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W-7 hydrochloride
T2079261714-27-0
W-7 hydrochloride (W-7 HCl), a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has antitumor activity.
  • $30
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Perphenazine
T109058-39-9
Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
  • $29
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Promethazine
T044560-87-7
Promethazine (Proazamine) is an analogue of anti-glaucoma prostaglandin (PG) .
  • $37
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Cloxacepride
T6804865569-29-1In house
cloxacepride is a CaM antagonist that is used to treat asthma disease.
  • $48
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Dibucaine
T036485-79-0
Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.
  • $31
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KN-92 hydrochloride
T85431431698-47-3
KN-92 hydrochloride is an inactive derivative of the selective Ca2+ calmodulin-dependent kinase II (CaMKII) inhibitor KN-93, which competitively blocks CaM binding to the kinase with a Ki of 370 nM.
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