CaMK

CAMK, also written as CaMK, is an abbreviation for the Ca2+/calmodulin-dependent protein kinase class of enzymes. CAMKs are activated by increases in the concentration of intracellular calcium ions (Ca2+) and calmodulin. When activated, the enzymes transfer phosphates from ATP to defined serine or threonine residues in other proteins, so they are serine/threonine-specific protein kinases. Activated CAMK is involved in the phosphorylation of transcription factors and therefore, in the regulation of expression of responding genes. CAMK also works to regulate the cell life cycle (i.e. programmed cell death), rearrangement of the cell's cytoskeletal network, and mechanisms involved in the learning and memory of an organism.There are 2 common types of CAM Kinase proteins: specialized and multi-functional CAM kinases.

Cat. No.	Product name	CAS No.	Purity
T16752	Rimacalib	215174-50-8	98%
T16752	Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).
TP1909L1	CALP2 acetate(261969-04-4 free base)	TP1909L1	98%
TP1909L1	CALP2 acetate is an antagonist of calmodulin showing high affinity for binding to the CaM EF-hand/Ca2+-binding site with a Kd of 7.9 µM. CALP2 acetate potently i...
TP2310	Autocamtide-2-related inhibitory peptide	167114-91-2	98%
TP2310	Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.
TP1216	CaM kinase II inhibitor TFA salt	TP1216	98%
TP1216	Autocamtide-2-Related Inhibitory Peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.
T1158	Phenoxybenzamine hydrochloride	63-92-3	98%
T1158	Phenoxybenzamine Hydrochloride is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and...
TP1271L	Calmodulin-Dependent Protein Kinase II 290-309 acetate		98%
TP1271L	Calmodulin-Dependent Protein Kinase II 290-309 acetate is an effective antagonist of Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM).
TP1921L1	Autocamtide-2-related inhibitory peptide, myristoylated acetate(201422-04-0 free base)	TP1921L1	98%
TP1921L1	Autocamtide-2-related inhibitory peptide, myristoylated acetate is a CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibit...
T16791	Rottlerin	82-08-6	98%
T16791	Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-...
TQ0137	A-484954	142557-61-7	98%
TQ0137	A 484954 is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.
T4185	Lavendustin C	125697-93-0	98%
T4185	Lavendustin C is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.
TP1217L	Autocamtide 2 TFA(129198-88-5 free base)	TP1217L	98%
TP1217L	Autocamtide 2 TFA is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). Autocamtide 2 TFA can be used in the CaMKII...
T6605	NH125	278603-08-0	98%
T6605	NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
T10667	Calmidazolium chloride	57265-65-3	98%
T10667	Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist (Kd: 3 nM), antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of ...
T14860	CaMKII-IN-1	1208123-85-6	98%
T14860	CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor (IC50: 63 nM). It has significantly high selectivity against CaMKIV, p38a, MLCK, Akt1, and PKC.
T68064	Elziverine	95520-81-3	98%
T68064	Elziverine is an orally available small molecule calmodulin antagonist.Elziverine in vitro treatment inhibited Ca-loading-induced acanthocyte formation in SHRSP,...
T23522	W-13 hydrochloride	88519-57-7	98%
T23522	W-13 hydrochloride is a calmodulin antagonist.
T2694	KN-62	127191-97-3	98%
T2694	KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.
T23525	W-9 hydrochloride	69762-85-2	98%
T23525	W-9 hydrochloride is a calmodulin antagonist.
T3546	STO-609	52029-86-4	98%
T3546	STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/mL)....
T8389	Trifluoperazine	117-89-5	98%
T8389	Trifluoperazine is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.