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Neuroscience CaMK

CaMK

CAMK, also written as CaMK, is an abbreviation for the Ca2+/calmodulin-dependent protein kinase class of enzymes. CAMKs are activated by increases in the concentration of intracellular calcium ions (Ca2+) and calmodulin. When activated, the enzymes transfer phosphates from ATP to defined serine or threonine residues in other proteins, so they are serine/threonine-specific protein kinases. Activated CAMK is involved in the phosphorylation of transcription factors and therefore, in the regulation of expression of responding genes. CAMK also works to regulate the cell life cycle (i.e. programmed cell death), rearrangement of the cell's cytoskeletal network, and mechanisms involved in the learning and memory of an organism.There are 2 common types of CAM Kinase proteins: specialized and multi-functional CAM kinases.
Cat No. product name
T0364 Dibucaine Dibucaine, a local anesthetic of the amide type, is now usually used for surface anesthesia.
T0445 Promethazine Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
T1090 Perphenazine Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
T1090L Prochlorperazine Prochlorperazine is an antipsychotic phenothiazine derivative.
T1146 Nifedipine Nifedipine is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and v...
T1158 Phenoxybenzamine hydrochloride Phenoxybenzamine Hydrochloride is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive an...
T1659 Melatonine Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness an...
T16752 Rimacalib Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).
T16791 Rottlerin Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η...
T20792 W-7 HCl W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and ha...
T2159 CaMKP Inhibitor CaMKP Inhibitor can inhibit CaMKP.
T2606 KN-93 Phosphate KN-93 Phosphate is a potent and specific CaMKII inhibitor (Ki: 0.37 μM), no inhibitory for PKC, APK, MLCK or Ca2+-PDE activities.
T2694 KN62 KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.
T2697 KN93 KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.
T2946 Tanshinone IIA sulfonate sodium Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator ...
T3546 STO609 STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/m...
T3650 STO-609 acetate STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for the...
T3777 Praeruptorin A Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2...
T3S0807 Berbamine 1. Berbamine has high binding affinity toward the (GGA);G-quadruplex. 2. Berbamine and its derivatives are promising agents to suppress liver cancer growth by t...
T4530 KN-92 phosphate KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to ...
T6605 NH125 NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
T8543 KN-92 hydrochloride KN-92 hydrochloride is an inactive derivative of KN-93. KN-93 is a selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor, competitively blocking CaM ...
TP1216 CaM kinase II inhibitor TFA salt Autocamtide-2-Related Inhibitory Peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.
TP1217L Autocamtide 2 TFA(129198-88-5 free base) Autocamtide 2 TFA is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). Autocamtide 2 TFA can be used in the CaMK...
TP1403L Syntide 2 acetate(108334-68-5 free base) Syntide-2 acetate is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 µM).
TP1921L1 Autocamtide-2-related inhibitory peptide, myristoylated acetate(201422-04-0 free base) Autocamtide-2-related inhibitory peptide, myristoylated acetate is a CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibi...
TP2310 Autocamtide-2-related inhibitory peptide Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.
Dibucaine
T0364CAS 85-79-0
Dibucaine, a local anesthetic of the amide type, is now usually used for surface anesthesia.
Promethazine
T0445CAS 60-87-7
Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
Perphenazine
T1090CAS 58-39-9
Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
Prochlorperazine
T1090LCAS 58-38-8
Prochlorperazine is an antipsychotic phenothiazine derivative.
Nifedipine
T1146CAS 21829-25-4
Nifedipine is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and v...
Phenoxybenzamine hydrochloride
T1158CAS 63-92-3
Phenoxybenzamine Hydrochloride is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive an...
Melatonine
T1659CAS 73-31-4
Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness an...
Rimacalib
T16752CAS 215174-50-8
Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).
Rottlerin
T16791CAS 82-08-6
Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η...
W-7 HCl
T20792CAS 61714-27-0
W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and ha...
CaMKP Inhibitor
T2159CAS 52789-62-5
CaMKP Inhibitor can inhibit CaMKP.
KN-93 Phosphate
T2606CAS 1188890-41-6
KN-93 Phosphate is a potent and specific CaMKII inhibitor (Ki: 0.37 μM), no inhibitory for PKC, APK, MLCK or Ca2+-PDE activities.
KN62
T2694CAS 127191-97-3
KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.
KN93
T2697CAS 139298-40-1
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.
Tanshinone IIA sulfonate sodium
T2946CAS 69659-80-9
Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator ...
STO609
T3546CAS 52029-86-4
STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/m...
STO-609 acetate
T3650CAS 1173022-21-3
STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for the...
Praeruptorin A
T3777CAS 73069-27-9
Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2...
Berbamine
T3S0807CAS 478-61-5
1. Berbamine has high binding affinity toward the (GGA);G-quadruplex. 2. Berbamine and its derivatives are promising agents to suppress liver cancer growth by t...
KN-92 phosphate
T4530CAS 1135280-28-2
KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to ...
NH125
T6605CAS 278603-08-0
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
KN-92 hydrochloride
T8543CAS 1431698-47-3
KN-92 hydrochloride is an inactive derivative of KN-93. KN-93 is a selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor, competitively blocking CaM ...
CaM kinase II inhibitor TFA salt
TP1216CAS TP1216
Autocamtide-2-Related Inhibitory Peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.
Autocamtide 2 TFA(129198-88-5 free base)
TP1217LCAS TP1217L
Autocamtide 2 TFA is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). Autocamtide 2 TFA can be used in the CaMK...
Syntide 2 acetate(108334-68-5 free base)
TP1403LCAS TP1403L
Syntide-2 acetate is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 µM).
Autocamtide-2-related inhibitory peptide, myristoylated acetate(201422-04-0 free base)
TP1921L1CAS TP1921L1
Autocamtide-2-related inhibitory peptide, myristoylated acetate is a CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibi...
Autocamtide-2-related inhibitory peptide
TP2310CAS TP2310
Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.