yc1

Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).

PXYC1 acts as an antagonist of ribosomal protein S1 (RpsA), a key protein in the translation process of Mycobacterium tuberculosis. PXYC1 exerts its antituberculosis activity by binding to the C-terminal domain (CTD) of the RpsA protein, exhibiting binding affinities (Kd) of 0.81 μM and 0.31 μM for the wild-type and Δ438A mutant, respectively.

PXYC12 is an antagonist of ribosomal protein S1(RpsA). RpsA is essential for the trans-translation process in Mycobacterium Tuberculosis (Mtb). The Kd values of PXYC12 for RpsA-CTD and RpsA-CTD Δ438A is 2.67 and 4.67 μM, respectively [1].

PXYC13 is an antagonist of ribosomal protein S1(RpsA). RpsA is essential for the Mycobacterium Tuberculosis(Mtb) trans-translation process. The Kd values of PXYC13 for RpsA-CTD and RpsA-CTD Δ438A is 7.61 and 8.50 μM, respectively [1].

Plogosertib (CYC140) is an orally active, selective, potent, and ATP-competitive PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib exhibits antiproliferative and anticancer activity and can be used for the study of solid and hematologic tumors. and hematologic tumors.

Antibiotic YC 17 is a biochemical agent.

YC 170 is a biochemical.

BODIPY-C12 Ceramide (B12Cer) is a fluorescently-tagged form of C12 ceramide, with excitation/emission maxima at 505/540 nm, respectively. It is a fluorescently-labeled sphingolipid and has been utilized for quantifying acid sphingomyelinase activity in the plasma of patients with Niemann-Pick disease.

CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.

YC-137 is a BCL-2 inhibitor, which selectively induces apoptosis of Bcl-2-overexpressing cells and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2.

C16 (2'(S)-hydroxy) Ceramide (d18:1/16:0) is a lipid molecule that can be used in life science related research. The CAS number of C16 (2'(S)-hydroxy) Ceramide (d18:1/16:0) is 890041-50-6.

Rhodady C10 (Compound C10) functions as an inhibitor of dynamin I GTPase. It effectively blocks receptor-mediated endocytosis (IC50: 7 μM), a process involving dynamin in clathrin-independent endocytosis, phagocytosis, and caveolae internalization.

Gemcitabine EP Impurity C-13C-15N2 is the 13C and 15N labeled compound of Gemcitabine EP Impurity C (T67291).

10-Deoxymethymycin (AntibioticYC 17) exhibits antibiotic activity against Gram-positive bacteria.

16:0 3-Deoxy-C1P (ammonium) is a type of ceramide.