x77

X77 is an effective non-covalent inhibitor of the main protease of SARS-CoV-2 ( SARS-CoV-2 M pro ) [1]. X77 binds to SARS-CoV-2 M pro with a Kd value of 0.057 μM [2].

(Rac)-X77 (MUN91789) is a potent SARS- CoV- 2 main protease inhibitor.

QPX7728 disodium (Xeruborbactam disodium) is a cyclic boronate inhibitor of many serine and metal-β-lactamases with antibacterial activity, used in research on bacterial infections.

QPX7728 bis-acetoxy methyl ester is an inhibitor of boronic acid β-lactamase.

QPX7728 (methoxy acetoxy methyl ester) is an inhibitor of boronic acid β-lactamase.

CCX777 is a partial agonist recruited to ACKR3 by β-arrestin-2 and is used in cancer research.

QX77 is a chaperone-mediated autophagy (CMA) activator.

QPX7728 is an of ultra-broad-spectrum boronic acid beta-lactamase.

Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.

(1R,2S)-Xeruborbactam disodium ((1R,2S)-QPX7728 disodium) is a boronic acid derivative with antibacterial activity, used in the study of bacterial infections.

Ivacaftor benzenesulfonate, used for cystic fibrosis treatment, is an orally bioavailable CFTR potentiator.

Ivacaftor hydrate is an orally bioavailable CFTR potentiator. It also is used for cystic fibrosis treatment.

Mavelertinib (PF-06747775) is an orally available, selective and potent EGFR tyrosine kinase (EGFR TKI) inhibitor with inhibitory effects on T790M/L858R and T790M/Del, and can be used in the study of oncology and respiratory diseases.

JAX-77 is a potent regulator of root architecture. It maintains primary root length while significantly increasing the number of lateral roots, optimizing the plant's overall root system structure. JAX-77 is the metabolic precursor to JAX-44 and can be converted into Indole-3-butyric acid (IBA). JAX-77 is applicable in the study of auxin biology and root development.

CCX-777 formic is a partial agonist that recruits β-arrestin-2 to ACKR3 (atypical chemokine receptor 3). It has applications in cancer research.

CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).

Ivacaftor-D9 is transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.

SARS-CoV-2 Mpro-IN-24 (Compound X77) is an inhibitor of SARS-CoV-2 Mpro with an IC50 value of 2.8 μM and acts as a non-covalent inhibitor of SARS-CoV Mpro with an IC50 value of 3.4 μM.