vincristine

Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-destabilizing agent for research on the treatment of hematologic cancers, such as leukemia and

Vincristine sulfate is an alkaloidal natural product that binds to microtubule proteins and inhibits the formation of microtubules, thereby inhibiting mitosis in tumor cells. Vincristine sulfate is used as a microtubule destabilizing agent in research studies for the treatment of hematologic neoplasms such as leukemias and lymphomas, as well as in studies related to sarcomas in children.

Vincristine-D3-ester sulfate istine-D3-ester (sulfate) is the deuterated form of Vincristine sulfate. Vincristine sulfate, an antineoplastic vinca alkaloid, inhibits the formation of microtubules in mitotic spindles, leading to cell cycle arrest at metaphase. It binds to microtubules with a Ki of 85 nM.

Vincristine-D3 sulfate is the deuterated form of Vincristine sulfate. Vincristine sulfate (T1270) is an antitumor vinca alkaloid that inhibits the formation of microtubules in the mitotic spindle, resulting in the arrest of dividing cells at metaphase. It binds to microtubules with a Ki of 85 nM.

Dehydronitrosonisoldipine is an inhibitor of sterile α and TIR motif-containing 1 and can be used in studies about neurodegenerative disorders. Dehydronitrosonisoldipine inhibits axon degenration and the Vincristine-activated cADPR production in neurons.

Anticanceragent 191 (Compound 2) is a probenecid derivative. It functions as an efflux inhibitor targeting cancer cells by inhibiting P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and/or multiple multidrug resistance proteins (MRPs). Anticanceragent 191 enhances the accumulation of vincristine within cancer cells and is utilized for cancer research.

P-gp inhibitor 24 (Compound 10) is an inhibitor of P-glycoprotein (P-gp) that blocks P-gp-mediated efflux of fluorescent dyes. This compound is effective in reversing multidrug resistance (MDR) and can enhance the cytotoxic effects of Vincristine and Etoposide on cancer cells.

Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerization (IC50: 1.2 μM). Besides that, it

A 30312 is a fused indole, which overcomes multidrug resistance in P388/Adr cells in vitro. It potentiates the cytotoxicity of the antitumor drugs Adriamycin, vincristine and vinblastine in multidrug-resistant cells with no effect on drug-sensitive parent P388 cells.

MS-073 (CP-162398) is a P-glycoprotein inhibitor (P-gp). The in vitro resistance to vincristine (VCR) was almost completely reversed in VCR-resistant P388 cells, and the resistance of VCR, adriamycin (ADM), etoposide, and actinomycin D in ADM-resistant hu

Simetride is used in the Reversal of resistance to vincristine in P388 leukemia.

Migrastatin is a bacterial metabolite that has been found inStreptomyceswith antimuscarinic and anticancer activities.1,2It binds to M1-5muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 μM, respectively) and inhibits calcium mobilization induced by carbamoylcholine in SK-N-SH cells (IC50= 28 μM), as well as in primary rat bladder smooth muscle cells.1Migrastatin inhibits the migration of EC17 esophageal cancer cells in a wound healing assay (IC50= 10 μg/ml) and 4T1 mouse mammary carcinoma cells in a chamber cell migration assay (IC50= 29 μM).2It enhances cytotoxicity induced by vinblastine in vincristine-resistant P388/VCR cells.3

Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) is a Schiff base-iron(III) complex with potential photosensitizing activity. It triggers tumor cell apoptosis by efficiently catalyzing intracellular ROS bursts under specific irradiation, leading to severe oxidative damage and mitochondrial dysfunction.

Piperafizine A is isolated from Streptoverticillium aspergilloides and potentiates vincristine antitumor potency.

EtDO-P4 is a cell-permeable, potent ceramide analogue that acts as a highly selective nanomolar inhibitor of UDP-glucose ceramide glucosyltransferase (UGCG), blocking glycosphingolipid (GSL) synthesis. By reducing GSL levels on cell membranes, it inhibits EGFR-induced ERK signaling and the activation of various receptor tyrosine kinases (RTKs), demonstrating anti-proliferative activity in multiple tumor models. Additionally, EtDO-P4 has been reported to reduce chemotherapy resistance and enhance the cytotoxicity of conventional anticancer drugs (such as vincristine and cisplatin).

P-gp inhibitor 5 is a potent P-glycoprotein (P-gp) inhibitor, reducing P-gp activity by a factor of 2.5 and 3.0 at 1.25 μM and 2.5 μM, respectively. It exhibits anti-proliferative effects on certain cancer cells and restores cellular sensitivity to Vincristine and Paclitaxel, reversing the multidrug resistant (MDR) phenotype of ABCB1/Flp-InTM-293 and KBvin.

Mps1-IN-3 hydrochloride is a potent and selective inhibitor of Mps1 (IC50: 50 nM) that exhibits inhibitory effects on the proliferation of glioblastoma cells and effectively sensitizes glioblastomas to vincristine in an in situ xenograft tumor model.

Kopsoffinol is a bisindole alkaloid that has been shown to have in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine-resistant human KB cells.

PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory activity in a variety of tumor types in vitro, and efficacy in SCID mice was shown in human tumor xenografts of MV-4-11 acute myeloid leukemia, MM.1S multiple myeloma, and DU-145 prostate cancer. Pharmacokinetic studies demonstrated relatively high oral bioavailability (71 %) with distribution to both plasma and bone marrow. No myelosuppression was seen in non-tumor bearing SCID mice given a single dose just under the acute lethal dose. The COMPARE algorithm in the NCI-60 cell line panel demonstrated that PC-046 closely correlated to other known tubulin destabilizing agents (correlation coefficients ≈0.7 for vincristine and vinblastine). Mechanism of action studies showed cell cycle arrest in metaphase and inhibition of tubulin polymerization. Overall, these studi......

Corydalmine hydrochloride is a chemical compound that suppresses spore germination in certain plant pathogenic and saprophytic fungi [1], serves as an effective oral analgesic agent with potent activity [2], and mitigates Vincristine-induced neuropathic pain in mice through the inhibition of an NF-κB-dependent CXCL1/CXCR2 signaling pathway [3].

Vinepidine (LY-119863) sulfate, a derivative of vincristine, exhibits antitumor activity .

Piperafizine B exhibits mild cytotoxicity in Moser cells, P388 cells, and Vincristine (VCR)-resistant P388 cells, with IC50 values of 23.8, 22.6, and 23.7 μg/mL, respectively. Piperafizine B acts synergistically with Vincristine to enhance VCR-induced cytotoxicity and improves leukemia outcomes in a mouse model.

Brittonin A, a methoxylated bibenzyl compound discovered in the liverwort F. inouei, exhibits anticancer properties. It demonstrates cytotoxic effects on KB cells and vincristine-resistant KB/VCR cells with IC50 values of 42.1 and 33.7 µM, respectively, as well as on K562 cells and adriamycin-resistant K562/A02 cells with IC50 values of 49.6 and 30.9 µM, respectively. At a concentration of 5 µM, Brittonin A enhances vincristine-induced cell death in KB/VCR cells and adriamycin-induced cell death in K562/A02 cells.

Scholaricine reverses multidrug resistance in vincristine-resistant KB cells.