v1-receptors

Terlipressin Acetate, a highly selective vasopressin V1 receptor agonist, on oxygen and glucose deprivation/re-oxygenation (OGD/R)-induced damage in intestinal epithelial cells (IEC-6).Terlipressin acetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin acetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research.

2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R and TRP channels. 2-Aminoethyl diphenylborinate also inhibits store-operated Ca2+ (SOC) channels and activates certain TRP channels (V1, V2, and V3). 2-Aminoethyl diphenylborinate also inhibits vasospasm. 2-Aminoethyl diphenylborinate can be used in research on calcium biology, cell signaling, oncology, and neurobiology.

Terlipressin is a potent vasoconstrictor that acts via V1 receptors on arteriolar smooth muscle cells.

Docarpamine is an orally active dopamine prodrug that is converted into active dopamine in the small intestine and liver through hydroxylation. In situations of spontaneous hypertension, it primarily activates peripheral D1-like receptors (D1-like receptor) to lower blood pressure and heart rate. Under normal blood pressure conditions, Docarpamine exhibits pressor effects and tachycardia by activating D1-like receptors, vasopressin V1 receptors (vasopressin V1 receptor), and α-adrenergic receptors (α-adrenergic receptor). Docarpamine is useful for studying renal vasodilation and diuresis.

Mozavaptan (OPC-31260) is a competitive antagonist of vasopressin receptors, targeting both V1 and V2 receptors, with IC50 values of 1.2 μM and 14 nM, respectively.