tropolone

Tropolone, a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion

7-Hydroxytropolone (3-Hydroxytropolone) is an antibiotic that exhibits activity against Gram-positive and Gram-negative bacteria, as well as yeasts and fungi. It also functions as an inhibitor of 2''-O-adenylate transferase.

Isatropolone A, a natural product with a 1,5-diketone moiety, has been reisolated from Streptomyces Gö66. This compound exhibits potent anti-Leishmania donovani activity, evidenced by an IC50 value of 0.5 μM [1].

3,4-Dimethoxytropolone can be isolated from the fermentation broth of Streptoverticillium hadanonense, and it shows activity against both Gram-positive and Gram-negative bacteria.

Hinokitiol (4-Isopropyltropolone) can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein induced by the agent. Also, Hinokitiol modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells.

Tropone (Cycloheptatrienone) is a non-benzene aromatic organic compound antiviral and antifungal.Tropolone derivatives inhibit the replication of HBV at the submicromolar level.