tracer

ROS tracer precursor, the synthesis precursor for [18F]ROStrace, serves in the production of ROStrace. This compound is instrumental in disease diagnosis.

Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates, primarily used for diagnosing neurodegenerative diseases [1].

Tau tracer 1 is a radiopharmaceutical agent designed specifically for visualizing Tau protein aggregates, commonly associated with neurodegenerative diseases. Its primary application lies in the diagnosis of these conditions.

XIAP Tracer mF-Smac, a fluorescently labeled peptide, functions as an acceptor dye in conjunction with a terbium-labeled BIR domain antibody for TR-FRET assays. The binding affinities (Kd values) are measured at 4.7 nM for BIR3 (XIAP) and 17.9 nM in XIAP polarization assays.

APE1-IN-1 is a potent inhibitor of purine/pyrimidine endonuclease 1 (APE1) that crosses the blood-brain barrier, exhibits potential antitumor activity, and enhances the cytotoxicity of the alkylating agent [methyl methanesulfonate] on cancer cells.

Fursultiamine (Alinamin F) is a disulfide derivative of thiamine, or an allithiamine. It has potential uses in the treatment of vitamin B1 deficiency.

Binodenoson (WRC 0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging[1].

JHU 75528 (JHU-75528) is a novel PET tracer with inhibitory effects on CB that can be used to study the cannabinoid system in schizophrenic patients.

Rhodamine B (Brilliant Pink B) is used as a tracer dye in water to determine the rate and direction of flow and transport.

MK-7337 is a high-affinity α-synuclein PET (positron emission tomography) ligand. Isotope-labeled MK-7337 serves as a PET tracer for imaging neurodegenerative diseases such as Parkinson's disease.

ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging.

THK5351 is a tracer involved in PET imaging for electron emission tomography imaging of Alzheimer's disease and cognitive impairment.

4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer used in the diagnosis of neurological diseases.

D-Glucose-13C6 (Dextrose-13C6) is an isotopic marker of D-Glucose, which can be used as a metabolic tracer for the study of metabolism-related diseases and metabolic processes of some substances in the body.

MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs) that exhibits high specificity and selectivity in binding to NFTs.

T807 (AV-1451) is a novel tracer of tau positron emission tomography (PET).

MK-3168 (12C) functions as a FAAH inhibitor, exhibiting IC50 values of 1.0 nM, 5.5 nM, and 1.7 nM for human, rhesus, and rat respectively. It demonstrates effective brain uptake and FAAH-specific signaling. Additionally, 11 C MK-3168 is applicable as a FAAH PET tracer.

P7-2302 inhibits PDE7 and PDE4B with IC50 values of 0.18 nM and 77.3 nM, respectively. It also inhibits the efflux of P-gp and BCRP (breast cancer resistance protein) and shows low uptake in rat brains. When labeled with 18F, P7-2302 can be used as a PET tracer.

G-quadruplexligand 3 (Compound 16) is a G-quadruplex ligand with the ability to chelate iron and exhibits anticancer properties. It stabilizes G-quadruplex structures within human leukemia Jurkat cells. Additionally, G-quadruplexligand 3 is localized in the cell nucleus and serves as a fluorescent nuclear tracer for the labile iron pool.

DUO-5-D8 2TFA (DUO-5 2TFA) is a deuterium-labeled analog of sea hare toxin, which can be used as a quantitative tracer in the drug development process and is often employed in the synthesis of ADC compounds.

PNU159682-EDA(D4) is a deuterium-labeled drug linker used for antibody-drug conjugates (ADCs). It is formed by combining PNU159682-D4 (a potent DNA topoisomerase II inhibitor) with EDA. It is commonly used in the synthesis of ADC compounds. The deuterium labeling can be used as a quantitative tracer during the drug development process.

Tau ligand-1 (Compound 75) is a ligand of aggregated tau protein that can penetrate the blood-brain barrier. In tissues affected by Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 shows high affinity for aggregated tau protein, with equilibrium dissociation constants (KD) ranging from 1 to 3.8 nM. It holds potential as a positron emission tomography (PET) tracer for imaging studies of tau-related diseases within the central nervous system.

KR31173 is an AT1 antagonist with an IC50 of 3.27 nM. When labeled with the 11C isotope, KR31173 can be used as a tracer for positron emission tomography (PET). In mice, KR31173 exhibits favorable biodistribution and pharmacological characteristics. It selectively binds to organs in CD-1 mice known to have a high density of AT1 angiotensin receptors.

AlF-PD-FAPI exhibits an affinity for FAP with an IC50 value of 0.13 nM. It is characterized by specific uptake, high internalization rate, and low extracellular excretion in vitro. AlF-PD-FAPI can serve as a FAP-targeting tracer.