tnik-in-2

TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.

TNIK-IN-1 (Compound 1) is a potent inhibitor of Traf2 and Nck-interacting kinase (TNIK), with an IC50 of 65 nM. TNIK is a pivotal effector in the Wnt/beta-catenin signaling pathway, essential for the maintenance of cancer stem cell properties and cellular proliferation. As a lead molecule based on the 4-phenyl-2-phenylaminopyridine scaffold, TNIK-IN-1 demonstrates significant antitumor activity by blocking TNIK kinase function and disrupting oncogenic signaling cascades, making it a valuable tool for researching Wnt-driven malignancies.

TNIK&MAP4K4-IN-1 (compound A-39) is a potent dual inhibitor of TNIK and MAP4K4/HGK, with IC50 values of 1.29 nM and <10 nM, respectively, in human hepatic stellate cell LX-2, and is applicable in cancer and fibrosis inhibition [1].

TNIK-IN-6 (Compound 9) acts as an inhibitor of Traf2 and Nck-interacting kinase (TNIK), with an IC50 of 0.93 μM, a kinase implicated in various neurological and psychiatric disorders [1] [2].

INS018 055 (TNIK&MAP4K4-IN-2) is a highly efficient TNIK and MAP4K4 inhibitor with antifibrotic activity. It can be used in research on idiopathic pulmonary fibrosis.