tianeptine

Tianeptine (Tianeptine sodium) is a selective 5-HT uptake facilitator in vitro and in vivo.

Tianeptine sodium salt, a selective serotonin reuptake enhancer (SSRE), is used to treat major depressive episodes.

Tianeptine metabolite MC5, an active derivative of the atypical antidepressant tianeptine produced through β-oxidation, exhibits selective G protein activation in bioluminescence resonance energy transfer (BRET) assays. Utilizing HEK293T cells expressing the human μ-opioid receptor (MOR) over the human δ-opioid receptor (DOR; EC50s = 0.454 and >100 µM, respectively), it demonstrates specificity. Moreover, this metabolite reduces immobility in wild-type mice during the forced swim test at a dose of 30 mg/kg, an effect not observed in MOR knockout mice, suggesting its antidepressant-like activity is MOR-dependent.

Tianeptine methyl ester shares a structural similarity with recognized opioids.

Tianeptine (Standard) is a reference standard of Tianeptine intended for quantitative analysis, quality control, and related biochemical research applications.

Tianeptine-[D4] (Standard) is a reference standard of Tianeptine-[D4] intended for quantitative analysis, quality control, and related biochemical research applications.

Tianeptine-[D6] Hcl (Standard) is a reference standard of Tianeptine-[D6] Hcl intended for quantitative analysis, quality control, and related biochemical research applications.