tesirine

MP-PEG8-VA-PABC-PBD Dimer is a drug-linker conjugates for ADC which is used in the treatment of several cancers. PBD Dimer is a DNA alkylating which inhibits DNA replication[1].

PBD dimer-4 (Compound 7) is a C1-substituted PBD dimer. This compound exhibits high DNA-binding affinity, effective DNA cross-linking ability, and potent cytotoxicity against MDA-MB-231 cells (IC50: 236 nM). PBD dimer-4 serves as a payload in the ADC drug Loncastuximab tesirine, utilized for treating various cancer types.

SG3199-Val-Ala-PAB is an intermediate in the synthesis of Tesirine, a conjugate of agent-linker for antibody-drug conjugates (ADCs) used in cancer research [1].

Mal-PEG8-Val-Ala-PABC is a cleavable linker used in the synthesis of Tesirine, an agent-linker conjugate for Antibody-Drug Conjugates (ADC) [1].

Val-Ala-PABC-Exatecan is a drug-linker conjugate comprising the cleavable linker Tesirine and the topoisomerase I inhibitor Exatecan, used in synthesising antibody-drug conjugates (ADCs).

Val-Ala-PABC-Exatecan trifluoroacetate is a drug-linker conjugate for antibody-drug conjugates (ADC), comprising a cleavable Tesirine linker, Val-Ala-PABC, and the topoisomerase I inhibitor Exatecan. This compound facilitates the synthesis of ADC molecules, including Mal-PEGn-amide-va-Exatecan [1].

Val-Ala-PAB is a building block in the synthesis of Tesirine (a.k.a. SG3249), a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload. Reagent in the preparation of pyrrolobenzodiazepine dimers and their antibody conjugates containing pepti

Alloc-Val-Ala-OH (((Allyloxy)carbonyl)-L-valyl-L-alanine) serves as a building block in the synthesis of Tesirine, which is a clinical antibody-drug conjugate (ADC) featuring a pyrrolobenzodiazepine (PBD) dimer payload. The Val-Ala sequence is cleaved specifically by cathepsin B. The Alloc group is stable towards piperidine and TFA, yet can be easily removed under mild conditions via palladium-catalyzed allyl transfer.