tco-peg4-tco

TCO-PEG4-TCO is a PEG-based linker used in PROTACs that connects two ligands critical for PROTAC molecule formation, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

BDP FL-PEG4-TCO is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that synthesises PROTAC molecules. Methyltetrazine-PEG4-maleimide contains a Tetrazine moiety and can undergo an iEDDA click with molecules containing a TCO moiety.

TCO-PEG4-acid is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands crucial for forming PROTAC molecules, thereby enabling selective protein degradation through the ubiquitin-proteasome system within cells.

(S)-TCO-PEG4-acid is a PEG-based linker for PROTACs, joining two essential ligands critical for PROTAC molecule formation, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TCO-PEG4-biotin is a PROTAC linker belonging to the PEG class.TCO-PEG4-biotin can be used to synthesise a range of PROTAC molecules.

TCO-PEG4-NHS ester is a PROTAC linker bridge in the PEG class, used for synthesizing various PROTAC molecules. As a cleavable and synthetic ADC, it is also utilized in the synthesis of antibody-drug conjugates (ADCs).

DBCO-PEG4-SS-TCO is a cleavable 4-unit polyethylene glycol (PEG) linker crucial for the synthesis of antibody-drug conjugates (ADCs)[1], facilitating the connection of the drug payload to the antibody and enabling targeted drug delivery.

TCO-PEG4-amine is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the selective protein degradation by leveraging the ubiquitin-proteasome system within cells. [PROTACs]

TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Methyltetrazine-PEG4-SSPy is a PROTAC linker within the PEG category, useful for synthesizing PROTAC molecules. It functions as a click chemistry reagent containing a Tetrazine group, capable of undergoing an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing a TCO group.

Bis-sulfone-PEG4-Tetrazine is a PROTAC linker belonging to the PEG class, used in the synthesis of PROTAC molecules. This compound acts as a click chemistry reagent and features a tetrazine group, enabling it to undergo inverse electron-demand Diels-Alder reactions (iEDDA) with molecules containing TCO groups.

(E)-TCO-PEG4-NHS ester is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

TCO-PEG4-VC-PAB-MMAE is an agent-linker conjugate used in antibody-drug conjugates (ADCs), consisting of a cleavable linker (TCO-PEG4-VC-PA) and the potent tubulin inhibitor MMAE [1].

Tetrazine-PEG4-amine (hydrochloride) serves as a cleavable 4-unit PEG ADC linker and a click chemistry reagent in the synthesis of antibody-drug conjugates (ADCs) [1]. It features a Tetrazine group capable of undergoing an inverse electron demand Diels-Alder reaction (iEDDA) with molecules that contain TCO groups.

Methyltetrazine-PEG4-hydrazone-DBCO, a cleavable 4-unit PEG ADC linker, serves as a click chemistry reagent in the synthesis of antibody-drug conjugates (ADCs) [1]. This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules. It also includes a Tetrazine group capable of engaging in an inverse electron demand Diels-Alder reaction (iEDDA) with TCO-bearing molecules.

Methyltetrazine-PEG4-aldehyde serves as a cleavable 4-unit PEG ADC linker in antibody-drug conjugates (ADCs) synthesis [1]. It functions as a click chemistry reagent, featuring a Tetrazine group capable of undergoing an inverse electron demand Diels-Alder reaction (iEDDA) with TCO-containing molecules.

TCO-GK-PEG4-NHS ester serves as an ADC linker, suitable for synthesizing [18F] AlF-NOTA-Tz-TCO-GK-2Rs15d, which demonstrates high affinity and immunoreactivity to HER2 [1]. This compound is a click chemistry reagent containing a TCO group that can engage in an inverse electron demand Diels-Alder reaction (iEDDA) with Tetrazine-containing molecules.

Ald-Ph-PEG4-bis-PEG3-methyltetrazine serves as a cleavable 7-unit PEG linker in the production of antibody-drug conjugates (ADCs) [1]. This compound, utilized as a click chemistry reagent, incorporates a Tetrazine group capable of engaging in an inverse electron demand Diels-Alder reaction (iEDDA) with TCO group-bearing molecules.

Tetrazine-diazo-PEG4-biotin functions as a cleavable 4-unit PEG ADC linker in the preparation of antibody-drug conjugates (ADCs) [1]. This compound acts as a click chemistry reagent, incorporating a Tetrazine group capable of conducting an inverse electron demand Diels-Alder reaction (iEDDA) with molecules possessing TCO groups.

Amino-PEG4-bis-PEG3-methyltetrazine serves as a cleavable seven-unit PEG linker in the creation of antibody-drug conjugates (ADCs) [1]. This click chemistry reagent includes a Tetrazine group capable of participating in an inverse electron demand Diels-Alder reaction (iEDDA) with TCO group-containing molecules.

Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) serves as a 10-unit PEG ADC linker in the fabrication of antibody-drug conjugates (ADCs) [1]. This compound also functions as a click chemistry reagent, featuring a TCO group capable of participating in an inverse electron demand Diels-Alder reaction (iEDDA) with Tetrazine-containing molecules.

(S)-TCO-PEG4-NHS ester, an ADC linker with four PEG units, utilizes its TCO group to facilitate an inverse electron demand Diels-Alder reaction (iEDDA) with Tetrazine-containing molecules.

Me-Tet-PEG4-NHS, an ADC Linker featuring four PEG units, leverages its Tetrazine group for a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds containing TCO groups.