tb-5

TB5 is a potent, selective, and reversible inhibitor of hMAO-B.

Glutamate-5-kinase-IN-2 (compound 54) is a potent glutamate-5-kinase (G5K) inhibitor with an MIC of 4.2 μM, exhibiting G5K inhibition by promoting conformational changes at the L-glutamate binding site. Glutamate-5-kinase-IN-2 has potential for anti-TB research [1].

Glutamate-5-kinase-IN-1 (compound 50) is a potent G5K inhibitor that modifies the ATP binding site architecture for enzyme recognition (MIC = 4.1 μM) and has potential for anti-TB research [1].

DprE1-IN-5 (Compound 10), a potent DprE1 inhibitor, exhibits anti-TB activity with an MIC of 4 μM against the Mtb H37Rv strain and demonstrates antimycobacterial efficacy against drug-resistant strains. Additionally, it possesses high microsomal stability [1].