t2307

T-2307 is an antibiotic commonly used against Candida, exhibiting broad-spectrum antifungal activity against most pathogenic fungi in vitro and in vivo. It selectively induces collapse of yeast mitochondrial membrane potential and can be used for invasive fungal infections.

Icotinib Hydrochloride (BPI-2009H) is the hydrochloride salt form of icotinib, an orally available quinazoline-based inhibitor of EGFR, with potential antineoplastic activity. Icotinib selectively inhibits the wild-type and several mutated forms of EGFR tyrosine kinase. This may lead to an inhibition of EGFR-mediated signal transduction and may inhibit cancer cell proliferation. EGFR, a receptor tyrosine kinase, has been upregulated in a variety of cancer cell types.

Nitrocaramiphen hydrochloride, a selective M1 muscarinic antagonist, inhibits binding to sigma sites in the brain.

Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor

NNC 05-2090 hydrochloride is a betaine/GABA transporter (BGT-1) inhibitor with an IC50 value of 10.6 μM.NNC 05-2090 hydrochloride can be used for the study of epilepsy and neurological disorders.

Somatostatin sst4 receptor agonist

NNC 63-0532 is a potentnociceptin receptor agonist, Ki=7.3 nM, EC50=305 nM.

NNC 05-711 (NO-711 hydrochloride) is a potent and selective inhibitor of GAT-1 (GABA transporter 1), which inhibits GABA reuptake and thereby increases GABA levels in the synaptic gap, exerting anticonvulsant and analgesic effects.

Bioactive metabolite of nociceptin, antagonist of nociceptin-induced hyperalgesia

Nociceptin (1-7) acetate is a potent agonist of opioid receptor-like 1 (ORL1) receptor. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia and has antinociceptive activity.

Angiotensin AT2 receptor agonist

Novokinin acetate exhibited an affinity for the AT2 receptor with Ki of 7 nM, and its antihypertensive and vasorelaxing activities were blocked by PD123319, an AT2 receptor antagonist.