substance p (7 11)

Substance P (7-11) (Substance P 7-11(TFA)) is a C-terminal fragment of Substance P .

Substance P (7-11) acetate is a specific fragment of the neuropeptide Substance P, acting as a neurotransmitter and neuromodulator in the central nervous system, with its endogenous receptor being neurokinin 1 (NK1R), making it useful for neurophysiological and pharmacological research.

[Tyr6,D-Phe7,D-His9]-Substance P (6-11) is a tachykinin NK1 receptor antagonist that can counteract histamine-induced hyperalgesia.

[D-Arg1,D-Trp5,7,9,Leu11]-Substance P is a potent inhibitor of small cell lung cancer (SCLC) cell growth. As a neuropeptide antagonist, [D-Arg1,D-Trp5,7,9,Leu11]-Substance P effectively blocks colony formation stimulated by multiple neuropeptides such as vasopressin and bradykinin. It inhibits Ca2+ mobilization and mitogen-activated protein kinase activation induced by vasopressin or bradykinin. [D-Arg1,D-Trp5,7,9,Leu11]-Substance P also suppresses the growth of H-69 xenografts in nude mice.

YM49598 is a tachykinin receptor antagonist. YM49598 exhibited high binding affinities at NK(1) (pK(i) = 9.09 +/- 0.02) and NK(2) (pK(i) = 9.94 +/- 0.03) receptors, respectively. YM49598 was almost inactive but produced a potent inhibition (IC(50) = 11 +/

[Sar9]-Substance P acetate is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.