stomatitis

Betamethasone valerate (Luxiq) is a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions.

Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.

UNC0638 hydrate selectively inhibits G9a and GLP histone methyltransferases with IC50 values of 15 nM and 19 nM, respectively. It is effective in inhibiting invasion and migration of TNBC cells in vitro. Additionally, UNC0638 hydrate acts as an inhibitor of EHMT1/2 and induces the expression of fetal hemoglobin (HbF) in cultures of human erythroid progenitor cells. Furthermore, it exhibits antiviral activity against FMDV (foot-and-mouth disease virus) and VSV (vesicular stomatitis virus), demonstrating remarkable potency and selectivity across various epigenetic and non-epigenetic targets.

SMU-V18 is a vesicular stomatitis virus (VSV) inhibitor with an EC50 of 6.2 μM. It suppresses VSV-GFP fluorescence intensity, viral mRNA/protein expression, and progeny virus replication. SMU-V18 interferes with the early stages of viral infection and is effective against wild-type VSV (VSV-WT). Additionally, it suppresses VSV-GFP in mouse tissues and extends survival in mice. SMU-V18 is useful for studying vesicular stomatitis virus (VSV) infections.

Pitstop 2c is a Clathrin inhibitor with an IC50 of less than 2 μM. It binds to the Clathrin N-terminal β-propeller domain, impairing Clathrin's function and dynamics, and blocking the entry of vesicular stomatitis virus (VSV). Pitstop 2c inhibits clathrin-mediated endocytosis (Endocytosis) but does not inhibit non-clathrin-dependent endocytosis.

Justicidin C, a lignan compound, exhibits potent antiviral properties, particularly against vesicular stomatitis virus, with minimal cytotoxicity observed in rabbit lung cells (RL-33) [1].

VSV-G Peptide is a 11 amino acid peptide derived from the Vesicular Stomatitis viral glycoprotein .

S-Adenosylhomocysteine (SAH) hydrolase is responsible for the reversible hydrolysis of SAH into adenosine and homocysteine. Inhibition of this enzyme leads to the accumulation of SAH within cells, thereby increasing the SAH to S-adenosylmethionine (SAM) ratio and subsequently inhibiting SAM-dependent methyltransferases. (−)-Neplanocin A, a potent and irreversible inhibitor of SAH hydrolase (Ki= 8.39 nM), exhibits significant antitumor activity against mouse leukemia L1210 cells and holds broad-spectrum antiviral properties. Its efficacy notably surpasses that of the reversible inhibitor 3-deazaneplanocin, especially in combating vesicular stomatitis, evidencing a higher potency with ID50 values of 0.07 μg/ml for Neplanocin A versus 0.3 μg/ml for 3-deazaneplanocin.

Mesoporphyrin IX (dihydrochloride), a photosensitizer, is effective in modifying liposomes and inserting into lipid vesicles. It disrupts the viral membrane structure of vesicular stomatitis virus (VSV), inducing cross-linking of VSV glycoproteins and thereby inhibiting viral activity.

9-Methylstreptimidone (AntibioticTS 885; NSC 248958) is a microbial metabolite initially isolated from Streptomyces S-885, known for its antifungal and antiviral properties. It is effective against various fungi, such as S. sake, S. fragilis, R. rubra, T. rubra, and C. albidus, with a MIC of 4-20 μg/mL. Additionally, it shows in vitro antiviral activity against poliovirus, vesicular stomatitis virus (VSV), and Newcastle disease virus (NDV) with a MIC of 0.02 μg/mL. Administering 9-Methylstreptimidone before infection can increase survival rates in mouse models infected with influenza A2 (H2N2) or Candida albicans.

Sanguinarine citrate (Pseudochelerythrine chloride) is an alkaloid derived from Sanguinaria Canadensis with antimicrobial, anti-inflammatory, and analgesic activity that is used in the treatment of oral inflammatory diseases such as stomatitis, bleeding gums, and laryngitis.

VSV-G Peptide acetate(103425-05-4 free base) is a 11 amino acid peptide derived from the Vesicular Stomatitis viral glycoprotein.

VSV-G is a vesicular stomatitis virus G (VSV-G) protein fragment. VSV-G protein is commonly used in biomedical research to pseudotype retroviral and lentiviral vectors, conveying the ability to transduce a broad range of mammalian cell types with genes of

H2-D b restricted epitopesVSVNucleoprotein (52-59) is a nonapeptide derived from the nucleoprotein of Vesicular Stomatitis Virus (VSV). It binds to MHC class I molecules to present itself to CD8+ T cells, thereby activating cytotoxic T lymphocytes (CTLs) that recognize and destroy cells expressing the corresponding antigen. This epitope is instrumental in the development of CTL vaccines against the Ebola virus.