sn-glycero-3-phosphocholine

sn-Glycero-3-phosphocholine (Choline glycerophosphate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have a potential for the treatment of Alzheimer's disease and dementia. sn-Glycero-3-phosphocholine rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer's disease. An Italian multicentre clinical trial on 2, 044 patients suffering from recent stroke were supplied Glycerylphosphorylcholine in doses of 1, 000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2].

1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine is a surfactant known for its role in promoting liposome formation. This compound is effective in studying the biological effects of ceramide and ceramide-1-phosphate. Additionally, it has significant applications in determining phospholipase A activity of lecithin-cholesterol acyltransferase within ether matrices.

1-Docosahexaenoyl-sn-glycero-3-phosphocholine, an ester product, is a phospholipid containing DHA (docosahexaenoic acid), often used in biomedical research as an important source of omega-3 fatty acids.

1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) is a phospholipid containing the unsaturated long-chain (18:1) oleic acid inserted at the sn-1 and sn-2 positions.

1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid utilized in liposomes for the study of lipid monolayers and bilayers.

1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine is an endogenous metabolite. 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine is a non-limiting exemplary phosphatidyl choline.

1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine is an endogenous metabolite identified in the aging mouse brain.

1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine is an endogenous metabolite.

1-Arachidoyl-sn-glycero-3-phosphocholine is a lysophospholipid (LyP).

1-(1(Z)-Hexadecenyl)-2-linoleoyl-sn-glycero-3-phosphocholine is a plasmalogen characterized by the presence of 1(Z)-hexadecenoic acid and linoleic acid at the sn-1 and sn-2 positions, respectively. It counteracts lead-induced reductions in cell viability and suppresses increases in reactive oxygen species (ROS) and oxidized phospholipids in HepG2 hepatocytes. In dogs with myxomatous mitral valve disease, serum levels of this compound decrease when their diet is enriched with medium chain triglycerides, fish oil, carnitine precursors, magnesium, and antioxidants.

1-Heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine, an endogenous metabolite present in blood, is utilized in research on pregnancy and sepsis [1] [2] [3].

1,2-Dibehenoyl-sn-glycero-3-phosphocholine (DBPC), a phospholipid integral to cell membranes, facilitates the formation of micelles, liposomes, and various artificial membranes [1].

1-Palmitoyl-sn-glycero-3-phosphocholine (16:0 Lyso PC) is a pro-inflammatory lysophosphatidylcholine that can be used in atherosclerosis research.

1-Oleoyl-sn-glycero-3-phosphocholine is a reference compound used for the analysis of lysolecithins (lysophosphatidylcholines or LPCs).

1-Stearoyl-sn-glycero-3-phosphocholine (L-ALPHA-LYSOPHOSPHATIDYLCHOLINE, STEAROY) is a chemical compound utilized in lipid metabolism studies.

1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine is a glycerophospholipid that plays a role in studying the effects of phosphatidylcholine (PC) on the lubrication of damaged mesothelial cells. It can be utilized to explore cell membrane functions and repair mechanisms, offering significant potential for applications in biomedical research.

1-Heptanoyl-2-hydroxy-sn-glycero-3-phosphocholine is a reagent used in biochemical reactions.

1,2-Dieicosenoyl-sn-glycero-3-phosphocholine (20:1(Cis)PC) is a phospholipid that enhances protein binding to liposomes. It acts as a component of biological membranes, increasing the fluidity of cell membranes. Additionally, 1,2-Dieicosenoyl-sn-glycero-3-phosphocholine plays a significant role in compound delivery systems, improving biocompatibility and targeting properties.

1-Tridecanoyl-2-hydroxy-sn-glycero-3-phosphocholine is a reagent used in biochemical reactions.

1-undecanoyl-2-hydroxy-sn-glycero-3-phosphocholine is a reagent used in biochemical reactions.

1-Palmitoyl-2-(6,7-dibromo)stearoyl-sn-glycero-3-phosphocholine is a phospholipid known for its excellent biocompatibility. It can be used in the preparation of large unilamellar vesicles.

1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine is a sterol-modified phospholipid known for stabilizing membrane bilayer structures and enhancing the activity of compound delivery mediated by liposomes. This compound is extensively utilized in biomedical applications to improve the efficiency of compound delivery. Additionally, 1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine can optimize intracellular release and distribution of compounds.

1-Hexacosanoyl-sn-glycero-3-phosphocholine (26:0 Lyso PC) is a long-chain fatty acid that can serve as a biomarker for X-linked adrenoleukodystrophy (ALD) in mice.

1,2-Dibutyryl-sn-glycero-3-phosphocholine is a reagent used in biochemical reactions.