sinomenine

Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.

Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.

Sinomenine N-oxide is one of the major metabolites of the cyclic metabolic mechanism of Sinomenine.

Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Tetrandrine inhibits voltage-gated calcium channels (ICa) and Ca2+-activated potassium channels.

Sinomenine (Standard) is a reference standard for research and analysis in studies involving Sinomenine. Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.

Sinomenine hydrochloride (Standard) is a reference standard for research and analysis in studies involving Sinomenine hydrochloride. Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.

7(R)-7,8-Dihydrosinomenine, an isoquinoline alkaloid extractable from Sinomenium acutum (Menispermaceae), exhibits anti-osteoclastogenic properties [1].

14-Episinomenine, an alkaloid, can be isolated from Stephania cepharantha [1].

1,1′-Disinomenine, an alkaloid extracted from the stems of Sinomenium acutum, exhibits modest inhibitory activity against A549 and Hela cells [1].

(9α,13α,14α)-4-Hydroxy-3,7-dimethoxy-7,8-didehydromorphinan-6-one is a major mechanism of Sinomenine. Sinomenine is an alkaloid derived from the Chinese herb Sinomenium acutum (Thunb.) Rehd. et Wils. (9α,13α,14α)-4-Hydroxy-3,7-dimethoxy-7,8-didehydromorphinan-6-one exhibits anti-inflammation effects.

Sino-C is a Sinomenine derivative with anticancer properties. It disrupts cholesterol homeostasis by upregulating crucial genes such as SREBF2 and HMGCS1, leading to intracellular cholesterol accumulation and lipid droplet formation. The metabolic disturbance induced by Sino-C further triggers lipid peroxidation and endoplasmic reticulum (ER) stress, initiating a unique mixed form of cell death that includes both apoptotic (cleaved PARP) and necrotic-like features. Sino-C is applicable in studies of colorectal cancer, lung cancer, and breast cancer.

(+)-Magnoflorine (Thalictrin) has sedative and anxiolytic effects, probably mediated by Magnoflorine through a GABAergic mechanism of action. Magnoflorine and Sinomenine have protective effects, are mediated by some mechanism other than prevention of micelle formation or protection of the erythrocyte membrane against osmotic imbalance.

Tetrandrine (Standard) is a reference standard for research and analysis in studies involving Tetrandrine. Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Tetrandrine inhibits voltage-gated calcium channels (ICa) and Ca2+-activated potassium channels.