siha

β-Aminopropionitrile (3-Aminopropionitrile) is a selective inhibitor of lysyl oxidase.

Isoliquiritigenin (ISL) is a flavonoid natural product that inhibits influenza virus replication (EC50=24.7 μM) and aldose reductase activity (IC50=320 nM). Isoliquiritigenin has antitumor activity.

Tubulin polymerization-IN-4 is an effective inhibitor of tubulin polymerization, and its IC₅₀ is 4.6 μM m. In HeLa cells, Tubulin polymerization-IN-4 can interfere with microtubule assembly and destroy the intracellular microtubule network, leading to cell cycle stagnation in G2/M phase, inducing cell apoptosis, and inhibiting cell clone formation and migration ability.

Antiproliferative agent-57 (compound M2) is a tumor angiogenesis inhibitor that suppresses VEGF secretion in SiHa cells under hypoxic conditions without inducing cytotoxicity (IC50=0.68 μM). It modulates the PI3K/AKT/mTOR and MAPK signaling pathways in tumor cells, thereby inhibiting the expression of HIF-1α and VEGF within tumor tissues.

Lw13 is a PROTAC targeting Hsp90, exhibiting maximal degradation efficacy at a concentration of 0.05 μM in Siha cells. Lw13 induces apoptosis and demonstrates potent antitumor activity both in vitro and in vivo.

E6-272, an inhibitor of HPV 16 (human papillomavirus 16), induced early and late apoptosis in HPV16-positive cervical cancer cells and inhibited the proliferation of HPV16-infected cells SiHa and CaSki with GI50 values of 32.56 and 62.09 nM, respectively.

Hydroxymycotrienin B is an ansamycin antibiotic that exhibits activity against human neck tumor cell lines, showing stronger inhibitory effects on human papillomavirus (HPV) gene-positive neck tumor cells, such as HeLa, CaSKi, and SiHa, compared to HPV gene-negative cells.

Hydroxymycotrienin A is an ansamycin antibiotic with the ability to inhibit human neck tumor cell lines. Its inhibitory effect is more pronounced on HPV-positive neck tumor cells (such as HeLa, CaSKi, and SiHa) compared to HPV-negative cells.