shu 9119

SHU 9119 is a potent ligand of human melanocortin receptors, exhibiting dual pharmacological properties: it acts as an antagonist at MC3R and MC4R, while functioning as a partial agonist at MC5R. The IC50 values of SHU 9119 against MC3R, MC4R, and MC5R are 0.23, 0.06, and 0.09 nM, respectively.

SHU 9119 acetate is a well-known antagonist of human melanocortin 3 and 4 (hMC3R, hMC4R) receptors and a partial hMC5R agonist. The IC50 values of human MC3R, MC4R and MC5R is 0.23, 0.06, and 0.09 nM respectively.

PG-931 TFA, a potent and selective agonist of the melanocortin 4 (MC4) receptor (IC50=0.58 nM) compared to the hMC3R (IC50=55 nM) and hMC5R (IC50=2.4 nM), is an analog of SHU 9119. This compound has demonstrated efficacy in reversing hemorrhagic shock and preventing multiple organ damage in vivo [2].