sh 42

SH-42 is a human Δ24-dehydrocholesterol reductase (DHCR24) inhibitor (IC50: 42 nM) that is selective and highly potent in inducing an increase in plasma desmethylferricinol levels.

D-688 serves as an inhibitor of Tau and Aβ. It can reverse the cytotoxicity in SH-SY5Y cells induced by Aβ1–42, displaying significant neuroprotective characteristics. Additionally, D-688 enhances the survival rate of transgenic fruit flies expressing the human tau protein isoform (2N4R).

D-687 is an inhibitor of Tau and Aβ. It effectively reverses the cytotoxicity induced by Aβ1–42 in SH-SY5Y cells, demonstrating significant neuroprotective properties.

Multitarget AD inhibitor-2 (Compound VN-19) is a versatile inhibitor targeting multiple sites, acting on acetylcholinesterase (AChE, IC50 = 0.14 μM), butyrylcholinesterase (BChE, IC50 = 11.6 μM), and monoamine oxidase B (MAO B, IC50 = 0.45 μM). It inhibits amyloid-beta protein Aβ1-42 self-induced aggregation with an inhibition rate of 47.3% at 20 μM and reduces ROS levels in SH-SY5Y cells with an inhibition rate of 80% at 25 μM. Multitarget AD inhibitor-2 can also improve cognitive decline in a scopolamine-induced Alzheimer's zebrafish model.

AChE/BuChE-IN-3 is a potent inhibitor of AChE (IC50: 0.65 μM) and BuChE (IC50: 5.77 μM) that crosses the blood-brain barrier and inhibits the aggregation of Aβ1-42, suitable for Alzheimer's disease research.