sgd 1882

SGD-1882 (PBD dimer) is a potent DNA alkylating/crosslinking agent serving as a cytotoxic PBD-class antibody-drug conjugate (ADC) payload molecule. SGD-1882 exhibits targeting properties toward mouse and human hematopoietic stem cells (HSCs) and acute myeloid leukemia cells.SGD-1882 can be used in ADC drug development.

Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylating agent used as an antibody-drug conjugate (ADC) cytotoxin, inhibiting DNA replication.

SGD-1882-Dap-Val is an intermediate used in the synthesis of antibody-drug conjugates (ADCs).

Rolinsatamabtalirine (ABBV 176) is an antibody-drug conjugate (ADC) that targets the Prolactin receptor (PRLR). It consists of the antibody Rolinsatamab, an enzymatically cleavable peptide linker, and the cytotoxic agent SGD-1882.