sdh 2

SDH-IN-2, a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.55 μg mL, demonstrates antifungal activity against plant pathogenic fungi, with EC50 values ranging from 3.82 to 9.81 μg mL.

Sitamaquine is an antileishmanial agent.1It is active againstL. donovani,L. infantum,L. mexicana,L. braziliensis, andL. tropica(EC50s = 9.5-19.8 μM). It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH), in a cell-free assay when used at concentrations ranging from 10 to 200 μM.2Sitamaquine (100 μM) increases intracellular levels of reactive oxygen species (ROS) and decreases intracellular ATP levels, as well as induces phosphatidylserine externalization, chromatin fragmentation, and depolarization of the mitochondrial membrane potential, markers of apoptosis, inL. donovanipromastigotes. 1.López-Martín, C., Pérez-Victoria, J.M., Carvalho, L., et al.Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomesAntimicrob. Agents Chemother.52(11)4030-4036(2008) 2.Carvalho, L.J.M., Luque-Ortega, J.R., López-Martín, C., et al.The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenaseAntimicrob. Agents Chemother.55(9)4204-4210(2011)

Succinate dehydrogenase-IN-2 (Compound 12x) is an inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 1.22 mg L. This compound also demonstrates antifungal activity, effectively inhibiting pathogens such as S. sclerotiorum, V. mali, G. graminis, R. solani, and B. cinerea with EC50 values ranging from 0.52 to 3.42 mg L.