saikosaponin

6''-O-acetylsaikosaponin A is an acetyl saikosaponin isolated from the roots of Bupleurum chinense. Itshows some osteoclast-inhibiting activities

Saikosaponin S, a natural compound, is isolated from Bupleurum scorzonerifolium [1].

Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropathic pain in CCI rats by inhibiting the activation of p38 MAPK and NF-κB signaling pathways in spinal cord. It can inhibit NMDA receptor current and persistent sodium current, and inhibit the TNF-α level, the IL-1β production, and cysteine-aspartic acid protease (caspase)-1 activity.

Saikosaponin B2 acts on HCV E2 and inhibits infection by several genotypic strains and prevents binding of serum-derived HCV onto hepatoma cells. Saikosaponin B2 (5 μM) induces differentiation of B16 melanoma cells, with potentiation of expressions of tyr

Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro.

Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.

Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.

Saikosaponin F is a natural compound found in Bupleurum (B.) falcatum L.

Saikosaponin b3 is isolated from the roots of Bupleurum falcatum L.. Saikosaponin b3 inhibits ACTH-induced lipolysis in the fat cells and exhibits analgesic effects.

Saikosaponin B4 is isolated from the MeOH extract of the roots of Bupleurum falcatum L.

Saikosaponin B1 (Standard) is a reference standard for research and analysis in studies involving Saikosaponin B1. Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro.

Saikosaponin B2 (Standard) is a reference standard for research and analysis in studies involving Saikosaponin B2. Saikosaponin B2 acts on HCV E2 and inhibits infection by several genotypic strains and prevents binding of serum-derived HCV onto hepatoma cells. Saikosaponin B2 (5 μM) induces differentiation of B16 melanoma cells, with potentiation of expressions of tyrosinase and melanogenesis.

Saikosaponin C (Standard) is a reference standard for research and analysis in studies involving Saikosaponin C. Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.

Saikosaponin A (Standard) is a reference standard for research and analysis in studies involving Saikosaponin A. Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropathic pain in CCI rats by inhibiting the activation of p38 MAPK and NF-κB signaling pathways in spinal cord. It can inhibit NMDA receptor current and persistent sodium current, and inhibit the TNF-α level, the IL-1β production, and cysteine-aspartic acid protease (caspase)-1 activity.

Saikosaponin D (Standard) is a reference standard for research and analysis in studies involving Saikosaponin D. Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.

Saikosaponin E is a natural product isolated from the herbs of Bupleurum.

Saikosaponin G is a natural product

Saikosaponin H is a natural saponin isolated from Radix bupleuri exhibiting inhibitory activity against Ishikawa cells (IC₅₀=17.21 µM).

1. Buddlejasaponin IVb (Saikosaponin 1b)(200 uM) can shorten thrombin time (TT) by 20.6 %, suggests that it has hemostasis efficacy.

11(α)-Hydroxynepasaikosaponin K (HOSSc) is a saikosaponin derived from Bupleurum scorzonerifolium Willd [1].

Saikosaponin I shows strong inhibition activity against influenza virus WSN33.

6′′-O-Acetylsaikosaponin b2 (compound 11), a natural saikosaponin, is identified in Bupleurum chinense [1].

Tibesaikosaponin V (TKV), a triterpene diglycoside isolated from the methanol extract of Bupleurum chinense DC roots, effectively inhibits lipid accumulation and triacylglycerol content in adipocytes without inducing cytotoxicity. It suppresses mRNA expression of nuclear transcription factors, including peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα), and impedes 3T3-L1 preadipocyte differentiation. Considering these properties, Tibesaikosaponin V is a promising compound for researching obesity and related metabolic disorders [1].

Nepasaikosaponin K is a small molecule compound isolated from Chaikosaponin root with anti-influenza and antiviral activity and can be used in the study of viral infections.